Digital-Pathology-Today

Magpie Communications

• October 2025 Digital Pathology Roundup

  Dec 1st 2025

  The October 2025 digital pathology roundup with Imogen Fitt of Signify Research is here. Recent activity in digital pathology and AI spans new partnerships, implementations, and product launches.
  
  Partnerships:
  Alpenglow Biosciences & VirDx: Collaborating to create large-scale 3D light-sheet microscopy datasets as ground truth for VirDx’s MRI-based prostate cancer diagnostics, using NVIDIA accelerated computing to tightly link radiology and pathology.
  Aiforia & Siemens Healthineers (Finland): After a broader European deal, Aiforia signed a local co-marketing/sales agreement with Siemens Healthineers’ Finnish affiliate to drive AI adoption in Finnish pathology as part of precision diagnostics.
  
  Implementations:
  Institut Curie: Entered a one-year agreement, funded by ARS Île-de-France, to use Aiforia’s CE-IVD clinical AI tools in routine pathology to support faster, more consistent diagnoses.
  One Dorset Pathology (NHS): Signed a 7-year managed equipment service to deploy FUJIFILM SYNAPSE® Pathology on AWS, integrating partners like Sysmex, Menarini, Ibex, Barco, and Augnito. The goal is 100% digital reporting and meeting the UK 10-day histology target by early 2026.
  Moffitt Cancer Center: Will implement four Pramana high-throughput scanners to support clinical and research work, including cytology and blood smears, with phased adoption through 2027.
  Ouest Pathologie & Dedalus: Planning the largest French roll-out of the integrated Diamic-DeepUnity LIS + imaging platform across Bretagne/Normandie via a 7-year plan starting December 2025, enabling AI, tele-expertise, and unified image management.
  
  Product launches & integrations:
  Aignostics Atlas H&E-TME: Now generally available, offering rapid, single-cell-level TME readouts and >5,000 metrics per image from routine H&E, initially targeting biopharma research.
  Proscia & Primaa: Integrated a skin AI module into Proscia’s platform for mitoses, hotspots, perineural invasion, and margin metrics in dermatopathology.
  PathPresenter: Its vendor-agnostic clinical viewer achieved CE-IVDR marking for primary diagnosis in Europe, complementing its FDA 510(k) and enabling broader EU clinical deployments.
  

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• September 2025 Digital Pathology Roundup

  Nov 1st 2025

  Digital Pathology Roundup – September 2025
  
  Funding:
  Cyted Health raised €44m Series B led by EQT Life Sciences with Advent Life Sciences and British Business Bank; existing investors Morningside and BGF joined. Funds will drive US expansion, strengthen UK commercialization, and broaden tests beyond EndoSign, its minimally invasive oesophageal cell collection paired with advanced biomarker assays.
  StratifAI closed €12.5m led by Picus Capital with Alven and others to clinically validate Polaris, a multimodal AI platform that fuses H&E histology, RNA-seq, and outcomes to generate prognostic and predictive spatial insights.
  
  Regulatory Approvals:
  Aiforia obtained CE-IVD for an AI tool detecting lymph node metastases, developed with University of Bern; the company claims up to 40% time savings in cancer staging.
  Primaa secured CE-IVDR for Cleo Breast, automating biomarker detection on biopsy and surgical specimens and reporting ~15% faster diagnostics; approval enables wider EU deployment and FDA preparation.
  Ibex earned CE-IVDR for HER2 IHC scoring within its Breast suite, developed with AstraZeneca and Daiichi Sankyo; the suite recognizes 54 breast tissue morphologies.
  
  Partnerships and Product Moves:
  Lunit partnered with Leica Biosystems to place its SCOPR PD-L1 tool in the Aperio AI Store; teamed with Agilent to co-develop AI-powered CDx solutions; and joined CellCarta to offer its pathology AI within CRO clinical trials workflows.
  Proscia launched Aperture to turn routine diagnostic data into real-time insights for biomarker validation, CDx development, and submissions; it also enhanced Concentriq AP for cytology and partnered with Datexim to add cytology AI.
  PathAI integrated Mindpeak’s 11 CE-IVD breast and lung tools (plus RUO assays), Stratipath’s CE-IVD prognostic breast model, and Primaa’s CE-IVDR breast and RUO dermpath tools into AISight Dx, further enlarging its CE-IVD ecosystem.
  

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• August 2025 Digital Pathology Roundup

  Sep 30th 2025

  Here is the August Digital Pathology Roundup with Imogen Fitt of Signify Research.
  
  1. Acquisitions:
  Tempus AI is buying Paige for $81.25M, mostly in stock. Beyond headlines calling it a “data deal,” Tempus gains Paige’s ~7M de-identified whole-slide images plus seasoned AI/regulatory assets: Paige holds FDA Breakthrough Device Designations and De Novo clearances across prostate, lymph node, and PanCancer Detect. Tempus will also assume Paige’s existing Microsoft Azure cloud commitment.
  
  Microscope maker Evident acquired AI-enabled scanner vendor Pramana—the first notable scanner-vendor acquisition in a while—prompting fresh questions about how hardware and AI stacks will consolidate.
  
  2. Partnerships:
  China’s Thorough Future announced a strategic partnership with Leica Biosystems to bring its multi-organ tumor-detection model (lung, stomach, prostate, intestine, lymph nodes) into Leica’s software; details remain light.
  KFBIO struck a distribution deal with Malaysia’s CytoVision to bring KFBIO’s scanners, AI, and software to Singapore and Brunei. CytoVision, active since 2023 in digitization and education, already works with two Singaporean hospitals, positioning KFBIO for regional traction.
  Techcyte extended its integration spree: (1) Modella AI’s PathChat co-pilot (and research-only PathChat DX, which has FDA Breakthrough status) to help pathologists summarize reports, interpret images, and query slides; and (2) DeepBio’s prostate and frozen-section algorithms. Initial DeepBio integrations will be RUO, with CE-IVD offerings in the portfolio and U.S. access planned via CLIA labs.
  
  3. Regulatory:
  ArteraAI secured FDA De Novo authorization for ArteraAI Prostate just 35 days after announcing Breakthrough Device status. It is now the first FDA-authorized AI tool to provide prognostic insights for patients with non-metastatic prostate cancer, and the decision creates a new product code that may streamline pathways for follow-on entrants.
  

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• July 2025 Digital Pathology Roundup

  Aug 29th 2025

  Here is the July 2025 Digital Pathology Roundup with Imogen Fitt of Signify Research.
  
  Partnerships:
  Owkin launched a 5-year partnership with Newcastle Upon Tyne Hospitals NHS Foundation Trust to apply agentic AI across drug discovery, development, and diagnostics. First up: an AI tool to screen for gBRCA mutations in breast cancer, with Newcastle running validation studies and contributing multimodal data via Owkin’s ATLANTIS network (20 institutions across 7 countries, 11 therapeutic areas.
  Lunit teamed with Microsoft to broaden access to cancer-detection AI through Azure-based model fine-tuning and agentic workflow tools; this follows Lunit’s growing DP footprint (e.g., SCOPE PD-L1 TPS integrating with Roche’s platform).
  AIVIS and AstraZeneca Korea signed an MoU to build an AI-driven HER2 diagnosis ecosystem, clinically implementing AIVIS’ Qanti IHC under the newer, more granular HER2 classification.
  
  Regulatory Milestones:
  Artera received FDA Breakthrough Device Designation (BDD) for ArteraAI Prostate, the first AI risk-stratification tool in prostate cancer predicting metastasis risk and disease-specific mortality from WSIs.
  CDx Diagnostics also earned BDD for WATS3D, which uses AI on 3D digital pathology images obtained via a proprietary brush for Barrett’s esophagus, dysplasia, and esophageal cancer—run in CDx’s CLIA/CAP/NYS-licensed lab.
  Other 2025 BDDs include Paige (PanCancer Detect), Roche (VENTANA TROP2 RxDx), and Modella AI (gen-AI co-pilot). Reminder: BDD is not clearance; historically only ~10% progress to full FDA clearance.
  
  AI Developments:
  Google Research/DeepMind expanded MedGemma with MedGemma-27B Multimodal (including EHR interpretation) and MedSigLIP (lightweight image–text encoder) spanning radiology, dermatology, digital pathology, ophthalmology; MedGemma integrates FHIR and medical text. A joint study showed illumiSonics’ MLI can generate virtual H&E-like images from unstained skin tissue that Modella AI’s PathChat DX (without prior virtual-histology training) could analyze with high concordance versus eight dermatopathologists reviewing virtual and matched chemical H&Es—signaling growing momentum for stain-free imaging.
  
  Funding:
  Imagene raised a $23M Series B led by Larry Ellison and Oracle.
  Scopio Labs unveiled its Complete Blood Morphology analyzer to automate peripheral smear review and analyze ~10× more cells than current practice; Viola Growth added $10M to Scopio’s Series D. Earlier in July, Scopio gained FDA clearance for a Decision Support System on X100/X100HT and a Peripheral Blood Smear app with AI-driven RBC morphology grading.
  

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• June 2025 Digital Pathology roundup

  Jul 31st 2025

  The June Digital Pathology Roundup with Imogen Fitt of Signify research is here.
  
  Funding:
  • RainPath AI raised €2.5M from Teampact.ventures, Xplore by Épopée Gestion, The Quest, Advance Lab, SHARPSTONE, about 15 angels, and Bpifrance. RainPath builds AI tools for virtual staining, smarter slide analysis, and structured reporting to cut reagent use and ease diagnostic bottlenecks. Funds will double headcount and advance product development and clinical validation.
  • PreciseDx closed $11M led by Eventide, Merck GHI, and Philips Ventures, with Labcorp, Quest, GenHenn, and others. Eric Converse was named CEO and Ed Sitar CFO. Proceeds support more clinical data, commercial expansion, and prep for a 2026 launch of PreciseBreast, which provides phenotypic and grading insights to predict breast cancer recurrence risk.
  
  Regulatory:
  • PathPresenter received FDA 510(k) for its Clinical Viewer for primary diagnosis, cleared with Hamamatsu NanoZoomer S360MD NDPI images on a Barco NV MDPC8127 display. Broader device and file support is expected.
  • PathAI secured FDA 510(k) for AISight Dx IMS for primary diagnosis with Hamamatsu S360MD and Leica Aperio GT 450 DX scanners; the IMS was first cleared in 2022 with the Philips Ultra-Fast Scanner. The FDA also approved a Predetermined Change Control Plan PCCP, allowing PathAI to add displays, scanners, file formats, and browsers without new 510(k) submissions, speeding platform expansion.
  • Evident announced that SLIDEVIEW™ DX VS200 earned the CEIVDR mark in Europe. The scanner supports fluorescence, polarization, darkfield, and phase contrast, adding competitive choice in Western Europe.
  
  Partnerships:
  • PathPresenter and CAP unveiled an immersive AI platform for CAP members to trial tools from multiple vendors, launching at CAP25 Sept 13 to 16, Orlando.
  • GI Alliance will adopt Lumea Viewer+ for its digital pathology entry, a significant deployment across 900 gastroenterologists and 400 plus sites.
  • Leica extended its CDx collaboration with Bristol Myers Squibb. Parent Danaher formed another CDx partnership with AstraZeneca.
  • Paige partnered with the Breast International Group to evaluate OmniScreen, focusing on novel biomarkers and real-world performance, especially in rare breast cancer subtypes. Paige also integrated with Roche Navify Digital Pathology.
  

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• May 2025 Digital Pathology Roundup

  Jun 30th 2025

  Here is May's Digital Patholog Roundup with Imogen Fitt of Signify Research.
  
  1. Digital Pathology as a Service (DPaaS): Histofy and Source BioScience announced a strategic partnership to enhance diagnostic workflows, starting with efficiency improvements and later expanding to deploy Histofy’s AI tools across Source’s UK-wide operations. Notably, Source BioScience is the UK’s largest histopathology provider and had previously acquired LD Path in 2022. This move reinforces the emerging trend of service-based digital pathology models, as seen with Inify Laboratories and PathologyWatch.
  
  2. Platform Integrations: French AI company Bioptimus launched its H-optimus-1 model on AWS Marketplace, improving accessibility for life sciences. Meanwhile, Labcorp introduced an integrated digital pathology platform across its central labs, combining Leica Biosystems’ Aperio GT450 scanners with Proscia’s Concentriq LS system. The initiative aims to streamline scanning, archival, and companion diagnostic development for global clinical trials.
  
  3. Artificial Intelligence: At Microsoft’s #Build2025, the company launched its Healthcare Multi-Agent Orchestrator, which includes Paige's Alba co-pilot for image-based pathology queries. Additionally, PictorLabs partnered with PathPresenter to integrate AI-based virtual staining into PathPresenter’s platform. Users can now apply virtual H&E, IHC, and special stains instantly on whole slide images for education, research, and clinical use—though FDA approval is still pending for PictorLabs’ solution.
  
  4. Funding: Medmain Inc. raised $3.3 million to enhance its PidPort image management system, expand infrastructure, and pursue regulatory approval for its AI tools. This brings 2025’s total Digital Pathology VC funding to $168 million across 10 vendors, reflecting strong investor interest.

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• April 2025 Digital Pathology Roundup

  Jun 1st 2025

  April’s Digital pathology Roundup with Imogen Fitt of Signify Research reflects strong momentum in digital pathology integrations, global AI expansion, and regulatory milestones.
  
  Partnerships & Integrations: Visiopharm + Indica Labs: Visiopharm’s Discovery image analysis software is now integrated into Indica Labs’ HALO Link (v4.1) platform. This paid add-on allows seamless viewing of annotations, ROIs, and analysis summaries across platforms.
  Paige + Burjeel Holdings: Paige’s AI solutions will be deployed across Burjeel’s 100 healthcare facilities in the MENA region (UAE, Saudi Arabia, Oman), expanding access to AI-powered pathology.
  Paige + Sectra: Sectra will distribute Paige’s AI tools, enhancing Sectra’s digital offerings in radiology, cardiology, and pathology.
  Mindpeak + DigitCells: Mindpeak’s AI algorithms will be integrated into DigitCells’ platform to enhance pathology automation.
  Google Cloud + Endeavor Health: New cloud-based platform aims to accelerate diagnosis, facilitate second opinions, and enable direct patient-pathologist engagement by allowing patients to view images and consult with pathologists.
  
  Regulatory Approvals: VIEWORKS: Korea’s VIEWORKS received CE IVDR certification for its VISQUE DPS LH510 scanner (supports tissue & cytology). The company plans European expansion. Roche: FDA granted Breakthrough Device Designation to Roche’s VENTANA® TROP2 CDx—first digital pathology companion diagnostic to receive this designation.
  
  Funding: Gestalt Diagnostics: Raised $7.5M Series A (total $12M) led by Cowles Ventures and others. Funds will accelerate AI development, commercialization, and FDA approval efforts.
  
  Leidos + Univ. of Pittsburgh: Leidos committed $10M over 5 years to fund the Computational Pathology Center, advancing research and clinical AI applications.
  
  Clinical Pilots: Region Skåne (Sweden): Initiated proof-of-concept for Paige’s Prostate Suite. Success may drive broader regional adoption.
  
  Listen to Digital Pathology Today on all major podcast platforms.
  

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• March 2025 Digital Pathology Roundup

  May 1st 2025

  March saw major developments across digital pathology, including regulatory milestones, foundational AI models, strategic partnerships, and significant funding wins.
  
  Regulatory Approvals:
  Epredia earned FDA 510(k) clearance for its high-volume E1000 Dx Digital Pathology Solution, capable of digitizing up to 1,500 slides per day. Despite the hardware’s impressive capacity and features like dual slide processing and automated quality control, its immediate clinical appeal may be tempered by institutions’ preference for redundancy over sheer throughput. Still, Epredia’s longstanding customer trust and emphasis on quality may help drive early adoption. Meanwhile, PathAI received EMA qualification for its AIM-MASH AI tool, which standardizes biopsy scoring for MASH trials—well timed given the FDA’s recent approval of the first drug for the condition.
  
  Foundation Models & Large Datasets:
  Bioptimus launched ‘H-optimus-1,’ a massive pathology foundation model trained on over 1 million H&E slides from 800,000+ patients. It more than doubles the dataset used for their previous model and builds momentum following January’s major funding round. At HIMSS, HistAI debuted its SPIDER initiative, aiming to create a 50-million-image open-source dataset covering 20 organs. The first release includes 3 pretrained models targeting skin, colorectal, and lung—an ambitious step toward accelerating AI discovery and collaboration.
  
  Partnerships:
  Quest Diagnostics teamed up with Google Cloud to deploy generative AI for enhanced data analytics and customer experience. While not immediately diagnostic, such tools are paving the way for future clinical AI applications.
  
  Funding:
  Proscia raised $50 million in a round led by Insight Partners, boosting its total funding to $130 million. The funds will support platform adoption, AI enhancements, and deeper collaborations with Agilent and Siemens. The company also hinted at a future IPO—marking a promising trajectory for this digital pathology innovator.
  

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• February 2025 Digital Pathology Roundup

  Mar 31st 2025

  February 2025 saw significant momentum in Digital Pathology, marked by strategic partnerships, platform expansions, and regulatory progress. Here is the February Round-up with Imogen Fitt of Signify Research.
  
  Indica Labs partnered with Versant Diagnostics to deploy the HALO AP platform across U.S. labs, emphasizing usability, collaboration, and AI integration. Despite FDA approval for the NanoZoomer S360MD scanner, implementation remains complex due to diverse installed scanner bases. Deciphex extended its partnership with Charles River Laboratories, integrating its Patholytix platform to manage toxicologic pathology data. Building on its Foresight AI, Deciphex aims to enhance lesion and tissue coverage, strengthening its dominance in pharma toxicology.
  
  In Digital Pathology–Genomics integration, Myriad Genetics and Lumea teamed up to streamline test ordering through Lumea’s platform, mirroring global trends toward centralized diagnostic systems. Additionally, Imagene and ArteraAI partnered with Tempus AI to distribute AI-powered assays, bypassing adoption barriers and potentially accessing Tempus' real-world datasets. These moves hint at deeper integration and potential acquisitions in the future.
  
  AI portfolio expansion continued, with Paige’s PanCancer Detect growing to cover 40+ tissue types, fueled by Virchow V2 (trained on 3.1M slides). Paige also secured 510(k) clearance for more scanners and increased accessibility via key platforms, signaling renewed clinical focus.
  
  Regulatory approvals were a highlight: Ibex Medical Analytics earned its first FDA 510(k) clearance for Prostate Detect, positioned as a safety net for pathologists. Meanwhile, Aiforia Technologies received IVDR certification in Europe, launching new CE-IVD models targeting breast and prostate cancer diagnostics.
  
  Finally, Sectra announced a digital pathology pilot with William Osler Health System in Ontario, part of a decade-long enterprise imaging strategy. Integration with existing IT systems is increasingly seen as critical, as vendors aim for long-term growth through enterprise imaging tenders globally.
  

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• January 2025 Digital Pathology Roundup

  Feb 28th 2025

  Here is January’s Digital Pathology round-up with Imogen Fitt of Signify Research.
  
  FDA Clearances: Paige received FDA 510(k) clearance for its FullFocus™ digital pathology viewer to support additional scanners, the Leica Aperio GT 450 DX and the Hamamatsu NanoZoomer S360MD. Previously cleared for the Philips IntelliSite Pathology Solution, this approval expands Paige’s flexibility in the competitive U.S. market. Similarly, Roche’s VENTANA DP 600 slide scanner gained FDA clearance, boasting a 240-slide capacity, surpassing its predecessor and strengthening Roche’s commercial positioning in the U.S.
  
  FDA Breakthrough Designations: Modella AI’s PathChat DX, a generative AI co-pilot for pathology, received FDA Breakthrough Device Designation. Developed at Mass General Brigham’s Mahmood Lab, PathChat DX builds on previously published research in Nature. However, this designation does not imply FDA clearance or guarantee future approval, with only 10% of such designations historically succeeding. The news underscores the growing role of generative AI in pathology while cautioning against premature assumptions about regulatory success.
  
  Platform Integrations: HistoWiz integrated AI tools from Aiosyn and AIRA Matrix into its PathologyMap platform, targeting research markets where AI adoption is more widespread. Unlike the clinical sector, research environments have seen fewer AI partnerships, but this move signals a trend toward broader AI collaborations in pathology research.
  
  Funding: Deciphex raised $32.3M in Series C funding, led by Molten Ventures and others, to support global expansion, platform development, and new AI models. The company also launched Diagnexia Analytix for drug development pathology. Meanwhile, Bioptimus secured $41M, bringing its total to $76M in under a year. Targeting biotech, medical, and cosmetic industries, Bioptimus plans to launch a new multi-scale, multi-modal foundation model in 2025. While AI advancements continue to generate excitement, commercial success depends on real-world clinical efficacy beyond just superior accuracy.
  

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• 2025 Digital Pathology Predictions

  Feb 24th 2025

  Imogen Fitt from Signify Research joins us for her predictions for Digital Pathology in 2025.
  
  Trend 1 – Genomics and Digital Pathology Markets Becoming Inextricably Linked
  Genomics and digital pathology are converging as distinct yet complementary fields. Increasingly, vendors are developing solutions that bridge the gap between these areas—for example, algorithms are being commercialized to extract genomic biomarkers directly from digital pathology images. Pharmaceutical companies are also collaborating with diagnostic and imaging firms, integrating multi-modal data from whole slide images to create digital companion diagnostics. Furthermore, strategic partnerships and investments (e.g., between molecular diagnostics firms and digital pathology vendors) are helping to merge the two fields. This integration not only enhances personalized medicine by providing a more comprehensive view of patient physiology but also improves laboratory workflows and pre-screening processes. Regions like Northern Europe have already started incorporating genomic data into digital pathology information management systems, demonstrating the growing market demand for such integration.
  
  Trend 2 – Generative AI Boosting Lab Productivity
  Generative AI (GenAI) is beginning to reshape lab operations by enhancing productivity and efficiency. Health tech and life sciences companies are actively exploring GenAI applications to automate report generation, consolidate knowledge, and streamline audit and quality control processes. Early initiatives from leading institutions like the Mayo Clinic and companies such as Sanofi illustrate the experimental use of GenAI in laboratory settings, particularly within digital pathology image analysis. Although the commercial impact of GenAI remains in its early stages, its potential to reduce manual tasks and enhance operational workflows is becoming increasingly recognized, indicating that GenAI will soon play a vital role in laboratory productivity improvements.
  
  Trend 3 – Continued Consolidation in the Marketplace
  The healthcare technology market is witnessing ongoing consolidation as vendors seek to strengthen their market positions by acquiring complementary businesses. This trend is driven by the need to expand capabilities and streamline product offerings, allowing companies to better meet the evolving demands of the industry. Such acquisitions enable vendors to combine expertise, reduce redundancies, and create more integrated solutions, thereby accelerating innovation and market penetration.
  
  Trend 4 – Digital Pathology’s Clinical Growth Driven by Adjacent Stakeholders and Vendor Types
  Although clinical adoption of digital pathology is still emerging, growth is being propelled by stakeholders from adjacent markets. BigTech companies—such as AWS, Microsoft, Google, and Dell—are entering the space, drawn by the revenue potential of whole slide image storage and real-world data management. Pharmaceutical firms are strategizing to secure reimbursement for digital companion diagnostics and exploring deployment models that integrate low-throughput pathology scanners in clinical settings. Additionally, radiology vendors are advocating for standardization efforts (like DICOM and Vendor Neutral Archives), which facilitate the integration of digital pathology systems with broader enterprise imaging platforms. New players in microscopy, laboratory information management systems (LIMS), teleradiology, and image exchange further underscore the expansive growth trajectory of digital pathology.
  
  Overall, while challenges remain, these four trends illustrate a dynamic and transformative future for healthcare, promising significant advancements in patient care, research, and operational efficiency.
  

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• November 2024 Digital Pathology Roundup

  Dec 31st 2024

  Happy Holidays Everyone! Here is the Digital Pathology Round-Up covering events in November with Imogen Fitt of Signify Research.
  
  There will be no December roundup but rather an assessment of the state of the industry and Predictions for 2025 coming in January.
  
  Customer Expansions: Ibex Medical Analytics announced significant expansions with existing customers. Alverno Laboratories, operating in Illinois and Indiana, launched Ibex’s AI-based breast cancer diagnostic platform, building on its earlier adoption of prostate diagnostics. A gastric platform is also in development. Meanwhile, France’s Institut Curie deployed Ibex’s prostate solution, with further expansions planned. These updates highlight the slow but steady adoption of AI in pathology, reinforcing its value despite lengthy validation processes.
  
  Partnerships: OptraSCAN secured $30M in Series B funding, led by Molbio Diagnostics, to accelerate R&D, expand global sales, and enhance AI pathology tools. Partnerships between genomics and digital pathology firms are expected to deepen as AI solutions advance. Lunit Oncology also announced a collaboration with AstraZeneca to develop AI-powered digital pathology tools for assessing non-small cell lung cancer (NSCLC) risks. Using Lunit’s SCOPE Genotype Predictor, this partnership focuses on identifying key mutations, marking Lunit’s first direct deal with a global pharmaceutical company.
  
  Third-Party Integrations: Owkin launched its MSIntuit CRC v2 test for colorectal cancer screening on Proscia’s Concentriq platform and joined the Proscia Ready alliance. The focus now shifts to the implementation of these integrations, whether as pop-ups or embedded tools, and the timeline for deployment. PathAI also announced the integration of tools from Deep Bio, DoMore Diagnostics, Paige, and Visiopharm into its AISight platform. With many IMS platforms adding third-party AI tools, differentiation strategies for vendors in an increasingly crowded market remain a key question
  
  

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• October 2024 Digital Pathology Roundup

  Nov 18th 2024

  Imogen Fitt from Signify Research joins us for the October Digital Pathology Roundup, which highlights significant developments in digital pathology and related fields, focusing on funding, telepathology, generative AI, and enterprise imaging.
  
  Funding: Mindpeak GmbH secured $15.3 million in Series A funding led by ZEISS Ventures and other notable investors, aiding product development and geographic expansion. Aignostics raised €31.4 million in Series B funding, backed by Athos Partners and Mayo Clinic Ventures, to enhance its platform for translational research and companion diagnostics, following a partnership with Bayer. StratifAI obtained €1.5 million in pre-seed funding from Neulogy Ventures and others to support digital biomarker development for breast cancer and biopharma services.
  
  Telepathology Services: Inify Laboratories announced its expansion into the UK market, focusing on prostate cancer diagnostics, backed by SEK 150 million funding to develop AI for gastrointestinal diagnostics. Originally part of ContextVision AB, Inify pivoted to telepathology using AI. In the US, NorDx adopted PreciPoint's Advanced Digital Pathology Solutions for frozen section diagnostics, emphasizing AI’s role in improving diagnostic turnaround times, a trend supported by investments from major players like Quest Diagnostics.
  
  Generative AI: Proscia introduced "Concentriq Embeddings" and a Developer Toolkit to assist AI development for life sciences. These tools use foundation models like DINOv2 and ConvNext to generate data embeddings from slide images, enabling customized AI workflows and integration.
  
  Enterprise Imaging: Gestalt partnered with Optum to integrate its PathFlow solution into Optum’s Enterprise Imaging Suite. This collaboration, involving Change Healthcare (acquired by Optum), represents a strategic move to advance digital pathology within enterprise healthcare platforms.These advancements underline the growing role of AI and digital solutions in pathology, fostering innovation and collaboration across the industry
  

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• September 2024 Digital Pathology Roundup

  Oct 4th 2024

  September's round-up highlights significant advancements in AI integration, structured reporting, real-world data (RWD), hematology, and funding in the digital pathology space.
  
  Aiforia Technologies partnered with Assistance Publique–Hôpitaux de Paris (AP-HP) to introduce AI-based prostate solutions into clinical use, backed by regional funding from Île-de-France. This initiative aims to study AI's impact in clinical care, with the potential for broader AI implementation across France, as AP-HP plans to expand AI usage across all its pathology departments.
  
  Proscia and Smart Reporting GmbH also joined forces, integrating SmartReports, a structured reporting tool, into Proscia’s Information Management System (IMS). Structured reporting enables the generation of standardized medical reports that facilitate large-scale data comparison and analysis. This tool is crucial for precision medicine and better understanding diseases in RWD studies. Smart Reporting has a strong presence in the radiology field and was highlighted in a comprehensive Imaging IT round-up.
  
  Proscia further introduced an RWD solution on its Concentriq® platform, integrating over 10 million pathology images with clinical and genomic data. This tool offers life sciences organizations access to de-identified patient data for drug development and marks a pivotal step toward making IMS platforms essential links between research and clinical applications.
  
  In hematology, Beckman Coulter Diagnostics and Scopio Labs expanded their partnership, adding the Full-Field Bone Marrow Aspirate (FF-BMA) application to their existing automated hematology solutions. This marks a successful continuation of their collaboration, which began in 2023.
  

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• August 2024 Digital Pathology Roundup

  Sep 13th 2024

  Imogen Fitt from Signify Research joins us to recap the news and events of August.
  
  Paige recently announced several key changes, starting with the appointment of Razik Yousfi as the new CEO. Paige is transitioning its diagnostic AI applications to a standalone solution compatible with other digital pathology platforms. Additionally, the company partnered with Indica Labs, integrating AI models into Indica’s workflow software and focusing on joint commercial efforts in pharma services, preclinical, and translational applications. This shift away from the IMS follows challenges such as market demand for interoperability and slow clinical growth. Paige also announced that its cancer research models, Virchow and PRISM, will be open-source, while advanced versions remain commercially licensed, aiming to boost algorithm usage through its collaboration with Microsoft.
  
  Roche expands its digital pathology open environment by integrating over 20 AI algorithms from eight collaborators to enhance cancer diagnostics and precision medicine.
  
  On the funding front, PreciseDx secured $20 million in a Series B round to commercialize PreciseBreast™ risk assessment. Labcorp and Quest Diagnostics' involvement signals growing interest from major labs in digital pathology (DP). Similarly, SigTuple raised $4 million to expand geographically, focusing on its AI-powered diagnostics product AI100, which received FDA clearance and is expanding into various global markets.
  
  In partnerships, Tribun Health teamed up with Ibex Medical Analytics to integrate Ibex’s AI solutions into its CaloPix platform, offering services in the EU, US, and Canada. Tribun Health’s future AI strategy emphasizes workflow efficiency, strategic collaborations, and interoperability, positioning the company for broader platform integration.
  
  Lastly, Ibex Medical Analytics and PathAI both received IVDR certifications, marking growth milestones for their prostate, breast, and gastric AI solutions. PathAI also announced new developments regarding its IMS platform. These moves highlight a growing momentum in AI-driven diagnostics and partnerships in the healthcare sector.
  

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• July 2024 Digital Pathology Roundup

  Aug 1st 2024

  The July Digital Pathology Round-up with Imogen Fitt of Signify Research is here.
  
  Nucleai and Proscia Partnership: Nucleai and Proscia have partnered to integrate Nucleai's AI Predictive Biomarker algorithms into Proscia's Concentriq platform. This collaboration aligns with the rising interest in digital companion diagnostics (CDx) in clinical trials and diagnostics. The demand for imaging biomarkers is driving rapid investments, especially from pharmaceutical companies, which will influence the digitization of clinical labs. Proscia also updated its digital pathology software, adding DICOM image support and a multi-AI overlay feature, enabling the use of multiple AI tools in the pathology workflow.
  
  UK Pathology and Genomics Collaboration: The National Pathology Imaging Co-operative (NPIC) partnered with CellPath to install two Whole Slide Imaging (WSI) scanners, connecting them to NPIC's national digital pathology system. These scanners will create a digital archive for the 100,000 Genomes Project, a precision medicine initiative. This integration aims to enhance genomics research and develop prognostic algorithms for patient stratification.
  
  Asia-Pacific Developments: 3DHISTECH announced Epredia China as its new distributor. Indica Labs announced new reseller agreements in the Asia-Pacific region, covering the Philippines, Thailand, Vietnam, and Malaysia. Indica Labs plans to pursue IVD registrations, indicating growth opportunities in the APAC region.
  
  Generative AI in Digital Pathology: Scientists from Weill Cornell Medicine and Dana-Farber Cancer Institute developed generative AI tools based on ChatGPT for digital pathology. These tools provide accurate responses to digital pathology queries and help pathologists with PathML, a library for DP image analysis. While impactful in academic circles, concerns about accountability and regulation limit their clinical application.
  
  Philips received 510(k) clearance for its IntelliSite Pathology Solution 5.1, signaling potential competitive dynamics in the US digital pathology market.
  
  Funding Announcements: Scopio Labs raised $42 million in a Series D round led by Fortissimo Capital, aiming to expand globally with a focus on the US market. Clarapath secured $36 million in a Series B-1 round to commercialize its automated microtomy system, SectionStar.
  

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• June 2024 Digital Pathology Roundup

  Jul 11th 2024

  A lot to talk about in June…
  
  ZayaAI introduced a Pathology Laboratory Information System (LIS), addressing integration issues between digital pathology IMS and outdated lab software. The acquisition of Visonex by PreciPoint further indicates market convergence.
  
  PathAI launched two AI products: PathExplore™ Immuno-Oncology Profiling (IOP) and IHC Explore1™, aimed at single-cell image analysis for biomarker discovery and companion diagnostics.
  
  Roche gained FDA 510(k) clearance for its VENTANA DP 200 scanner, marking rapid growth in the US market amidst increased regulation.
  
  Tempus AI went public, providing digital pathology services and patient data access, competing with vendors like Paige and PathAI through advanced algorithms for IHC and H&E staining.
  
  Imogen Fitt is Senior Market Analyst at Signify Research. During her tenure Imogen has completed studies on digital pathology, LabIT and the use of AI in drug development, expanding Signify Research’s diagnostics and life sciences business coverage.
  

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• SEASON 3, EPISODE 14 - Alan Lorimer - Digital Pathology in the Cloud

  Jun 28th 2024

  Moving digital pathology to the cloud. We're talking about cloud computing the features and components of the cloud and how it differs from on premise computing. What are the barriers and overlooked considerations in moving your operations to the cloud? What is the truth about storage costs in 2024? Is it still a concern or have the gains been eaten away by the increasingly large amounts of data we continue to generate?
  
  How can cloud computing unlock exciting new applications at a lower cost for organizations? And finally we discuss regulatory considerations for the cloud from the perspective of the FDA EU, GD CP and GCP in developing new drugs and diagnostics.
  
  Alan Lorimer, started his professional journey as an electronics engineer at the BBC. Over his 40-year career, he's founded or led four successful businesses. Notably, he drove an IT hosting company to a successful exit in 2011. He then specialized in IT due diligence for around 60 European companies going through some kind of transaction, sharpening his analytical prowess.
  
  In 2016, Alan pivoted to digital pathology, creating the innovative QDPconnect with OracleBio, leading to the launch of Sciento Technology. Alan's journey from the BBC to cloud computing exemplifies his relentless drive for tech innovation and industry impact.
  

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• SEASON 3, EPISODE 13 - Andre Esteva, PhD - Personalizing Treatment Decisions through Artificial Intelligence

  Jun 20th 2024

  Today we are discussing how treatment decisions can be personalized through artificial intelligence and digital pathology. Our guest is Andre Esteva of Artera. Atera’s first product is in prostate cancer. We discuss how AI can improve upon the current state of the practice which largely relies on making decisions based on clinical nomograms.
  
  We discuss the concepts prediction and prognosis and how both are incorporated into treatment decisions; what goes into developing and validating AI based algorithms in digital pathology and the importance of validating these algorithms in the appropriate studies specifically randomized clinical trials.
  
  There is one huge advantage of AI based digital pathology tools over genomics and molecular tools. Image based tools can be performed instantaneously rather than waiting days to weeks.
  
  Andre Esteva is a researcher and entrepreneur in medical artificial intelligence. He currently serves as CEO of Artera and was previously Head of Medical AI at Salesforce Research. He has worked at Google Research, Sandia National Labs, GE Healthcare, and has founded four companies.
  
  His research efforts have largely focused on medical AI diagnostics and precision medicine. His publications have made the covers of Nature and Nature Medicine, and have been featured in Cell, The Lancet, NeurIPS, and similar venues. These works have been widely covered by the WSJ, Fortune, BBC, The Economist, and hundreds of other news outlets.
  

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• The Journey to Pathology 3.0, EPISODE 1 - Branko Perunovic, MD, FRCPath

  Jun 13th 2024

  What is pathology 3.0?
  
  We are at an inflection point. The demand on pathologists in laboratory medicine is greater than ever. Demographics and healthcare needs of the population are shifting. New technologies such as digital pathology and molecular diagnostics are now a reality. The rules of the game are changing. There are times in any industry where massive change is inevitable and there is great opportunity to grow. And for this, we need a new mindset.
  
  Pathology 1.0 was transactional. Clinicians would send in the specimen we would send the results. Passive and fragmented. Not responsive.
  
  Pathology 2.0 involved consolidation, taking advantage of economies of scale and scope. But still transactional and fragmented.
  
  Pathology 3.0 is connected, intelligent and evolving. Pathologists can add unique value and build on previous waves of consolidation. It transcends the boundaries of disciplines and organizational silos. It integrates new technologies and is interactive.
  
  Branko Perunovic is Chief Medical Officer at Black Country Pathology Service, where he leads the pathology consolidation and the delivery of high-quality and innovative pathology services.
  
  His journey has taken him through various aspects of healthcare, including transforming pathology services, consolidating labs, fostering collaborative team dynamics, and pioneering the integration of digital pathology and digital innovation in laboratory medicine.
  
  His ultimate goal is simple: to improve patient care, making the pathology service the provider, employer, and investment of choice. Together with a dedicated team, we can achieve this vision and create a healthcare landscape that truly puts patients first.
  

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• Monthly Recap with Imogen Fitt - May 2024

  Jun 7th 2024

  The May Digital Pathology Roundup with Imogen Fitt of Signify Research is here.
  
  We cover 3 main topics this month:
  1. Updates and new releases in the scanner sector, Including 3DHISTECH
  2. Cloud and Ai marketplace developments including Aiforia
  3. The state of AI adoption and real-world implementations, with news from Ibex and Aiforia
  
  We also clarify some news from last month. PathAI in its entirety isn't being sold off to Quest. Quest will be acquiring 'select assets of PathAI Diagnostics', which will evolve into Quest's 'AI and digital R&D and solutions center'.
  
  Imogen joined Signify Research in 2018 as part of the Healthcare IT team. During her tenure Imogen has completed studies on digital pathology, LabIT and the use of AI in drug development, expanding Signify Research’s diagnostics and life sciences business coverage.
  

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• SEASON 3, EPISODE 13 - Torbjørn Furuseth, MD - Is it Time for Digital Biomarkers?

  May 16th 2024

  Is it time for digital biomarkers? Our guest today is Torbjørn Furuseth of DoMore Diagnostics.
  
  Predictive and prognostic algorithms may be the crown jewel of digital pathology, enhancing our value as pathologists to be the chief purveyor of this information in assisting doctors and patients.
  
  We discuss the unmet need in oncology, particularly in colon cancer, to develop predictive and prognostic tools to guide therapy. We also explore the advantages of digital pathology over molecular tools and how these methodologies can be used together in some cases. What goes into the development and validation of such tools? Why might new and innovative CPT codes be necessary to encourage innovation in digital pathology? How do reimbursement challenges affect the innovation pipeline for digital pathology? And in the increasingly global marketplace, what considerations must we take into account to help patients across the world?
  
  Torbjørn is the CEO and Co-Founder of DoMore Diagnostics, a leader in AI and deep learning precision diagnostics for digital pathology, focused on outcome prediction to personalize cancer treatment. He is a medical doctor with broad experience in life sciences and oncology. After practicing as a physician in radiology and sports medicine, he transitioned into business and management as a consultant at McKinsey & Company, where he served several pharma and healthcare clients. Following McKinsey, he has held multiple leadership positions in Norwegian life science companies and served as CFO at two immuno-oncology companies. Torbjørn’s vision is to play an important role in an important innovation.
  

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• Monthly Recap with Imogen Fitt - April 2024

  May 9th 2024

  We have a new feature on Digital pathology Today: a monthly recap of the biggest and latest industry developments with Imogen Fitt of Siginfy Research.
  
  April was a huge month, and it seems the pace of innovation and new developments individual pathology is increasing at a breakneck speed.
  
  This month's recap features updates on AI Co-development partnerships, FDA approvals, acquisitions as well as Imogen's thoughts on the recent USCAP meeting in Baltimore.
  
  Imogen joined Signify Research in 2018 as part of the Healthcare IT team. During her tenure Imogen has completed studies on digital pathology, LabIT and the use of AI in drug development, expanding Signify Research’s diagnostics and life sciences business coverage.
  

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• SEASON 3, EPISODE 12 - Krishna Bala, PhD - "Where Work Gets Done and Data Lives," The Enterprise Pathology Platform

  May 2nd 2024

  In this episode we discuss the enterprise pathology platform and how it is so much more than image management. “It’s where work gets done and data lives,” according to Krishna Bala of Proscia. We discuss the components or steps involved in digital pathology workflow. How do we make it all seamless?
  What is the appropriate level of pathologist involvement in the design and implementation of such systems? How can software engineers acquire domain expertise? What does integration mean and how can we incorporate exciting new AI tools into our daily practice? We discuss the benefits of an open platform and why our guest thinks this model will ultimately win out.
  Krishna Bala is currently Sr. VP of Engineering at Proscia, a leading provider of digital and computational pathology solutions. In this role, he leads the development of Proscia's Concentriq enterprise pathology platform, which is used by leading life sciences organizations and top diagnostic laboratories. Krishna is an experienced healthcare technologist with more than 20 years of experience in software development, data engineering, and AI/Machine-Learning. He is also an entrepreneur with several successful exits including an IPO as CTO/Founder. Krishna has a Ph.D. in Electrical Engineering from Columbia University in New York.
  

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• SEASON 3, EPISODE 11 - Chhavi Chauhan, PhD - The Need for Ethics in Digital Pathology

  Apr 25th 2024

  Today we dive into a field that hasn't existed until very recently - ethics in AI and digital pathology. What is ethics and how is it relevant in digital pathology? We all want to do the right thing, don't we? Maybe easier said than done? Do we even have a working definition of AI that people can agree on?
  We discuss a framework for ethics, incorporating such principles as fairness and inclusiveness, transparency, and algorithmic bias to name a few. What are the risks of artificial intelligence for pathologists, either real or imagined?
  Dr. Chhavi Chauhan is Director of Scientific Outreach at the American Society for Investigative Pathology, a Program Manager for the Women in AI Accelerate & Raise Program, and currently serves on the Boards for 8 different mission-driven organizations in the spheres of scholarly publishing, digital pathology, AI Ethics, & youth education.
  She is a former biomedical researcher, expert scholarly communicator, and a sought-after mentor in the fields of scientific research, scholarly publishing, and AI Ethics, especially for women and minorities. She is a thought leader, a renowned international speaker, and a strong advocate for equitable and accessible healthcare.
  She was named in the AI Makers 150 AI & Analytics Leaders & Influencers 2021 List, the 100 Brilliant Women in AI Ethics 2022 list, the Top 100 Women of the Future 2023 List, and was listed as a Finalist for the AI in Researcher Award '23 from Women In AI.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=7C4NW1Z-9IQW7B9

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• SEASON 3, EPISODE 10 - Lisa-Jean Clifford - A Fresh Start for Pathology

  Apr 18th 2024

  Lisa-Jean Clifford is Chief Operating Officer and Chief Strategy Officer at Gestalt Diagnostics. We discuss parallels between pathology and radiology in their digital journeys, the steps involved in going digital, how to keep the various stakeholders engaged and enthusiastic. We posed the question: “ Have we finally made the business case for digital pathology?”
  Lisa-Jean tells us about the user experience for pathologists in the digital environment and how many of her clients are having a faster more streamlined experience than with glass slides. We discuss the promise of new technologies in digital pathology and how in many ways, digital pathology is a fresh start for pathology.
  For more than 2 decades, Lisa-Jean Clifford has been a noteworthy leader in the high-tech healthcare solutions space. Her passion for making a positive impact on the lives of patients through technology can be traced back to her tenure at McKesson and IDX, now GE Healthcare, where she served in vital business development and marketing roles and to Psyche Systems, an LIS solution provider, where she was the CEO for eleven years.
  Now, recognized as an industry expert, she actively participates in numerous boards including the Association of Pathology Informatics and MLO’s Editorial Advisory Board. She is widely published in many top laboratory publications and noteworthy news sources, such as Forbes, CAPToday, Medical Laboratory Observer, and Health Data Management. Also, she is a highly sought-after speaker and focuses on delivering valuable content in critical areas such as lab automation including software and interoperability, digital pathology, AI in pathology, lab informatics, oncology, and women’s health.
  

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• Season 3, Episode 9 - Ken Bloom, MD - "It Has to be Led by Somebody"

  Apr 11th 2024

  This episode with Dr. Ken Bloom of Nucleai, we examine the beginnings of telepathology, which led to what we now know as digital pathology in the 1980s. We trace the journey to now, focusing on seminal events in the industry, such as computational pathology, computer-assisted image analysis, the development of CPT codes, the importance of the TCPC split, particularly in the reference lab setting,
  
  We also discuss the democratization of immunohistochemistry in connection with digital pathology and touch on recent developments in the assessment of tumor heterogeneity, AI algorithms, and spatial analysis.
  
  Additionally, we explore the role of pathologists in the era of precision medicine, and the potential for integration of pathology with radiology.
  
  Dr. Kenneth J. Bloom is currently the head of pathology at Nucleai. He has more than 35 years of clinical experience in pathology, oncology, telemedicine, and bioinformatics. Dr. Bloom previously served as the Chief Medical Officer at Invicro and Ambry Genetics. He was also President and Head of Oncology and Immunotherapy for Human Longevity Inc.
  
  He played an instrumental role in designing the business strategy that grew Clarient from a startup with no revenue to its acquisition by GE. He oversaw the development of hundreds of laboratory-developed tests, including those using IHC, ISH, Flow Cytometry, and Molecular methods.
  
  Dr. Bloom spent 15 years at Rush Medical College, where he held various titles, including Director of Laboratory Operations and Chief Information Officer of the Rush Cancer Institute
  

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• SEASON3, EPISODE 8 - Jon Wetzel - Accelerating Research with Computer Assisted Pathology

  Oct 20th 2023

  We know that there are certain tasks pathologists are often not very good at or may prefer not to do, such as counting cells or estimating tumor volume. Why not free them up from these tasks and allow them to focus on other areas where they can add more value?
  As technology accelerates and drug discovery quickens, there are more and more studies being conducted and fewer pathologists available to participate. What if we could automate some of these processes to alleviate the burden on pathologists?
  At the heart of clinical research, particularly in oncology, is the patient specimen, usually in the form of a paraffin block. What if we could reimagine the way we unlock the precious DNA and RNA from the paraffin block? What if researchers could view digital images of HD sections and select ones that meet their precise needs for a study before the blocks even arrive in their lab, getting exactly what they want and saving months of effort?
  Jon Wetzel, COO of Trimetis, is a researcher at heart, with over 24 years of experience in the life sciences and 20 years of management in startup biotech companies. He has created several companies, most recently co-founding FoundationBio, which is now part of TriMetis. Jon has served in academia and senior roles in the industry with the University of Michigan, UCLA, Genelogic, Rosetta Inpharmatics, Asterand, and AdeptBio. Jon holds several certifications from the University of Michigan for Lean and Six Sigma and is a Certified Six Sigma Black Belt.
  We discuss computer-assisted pathology and the suite of software tools that Jon and the team at TriMetis have been developing to accelerate progress in the biospecimen and tissue-based research field.
  

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• SEASON 3, EPISODE 7 - Christopher Ung - The CRO of the Future

  Oct 12th 2023

  What does the CRO of the future look like? In diagnostics we seem to be inundated with more platforms, more analytes more “-omics” and more pathways. How do we make sense of it all? What is the future of multi-omic analysis and what role will digital pathology play in understanding biological pathways, clinical trials, multi-omics and the development of companion diagnostics?
  Christopher Ung, Chief Scientific Business Officer at CellCarta, has 22 years of experience in the field of digital pathology. He has made a significant impact by leading innovative solutions in the realm of companion diagnostics. He led the development of HerceptTest, and in 2009 built and connected pathology labs in four different countries with a digital pathology system. Christopher 's passion for digital pathology stems from a belief in the potential for technology to revolutionize the way pathology is practiced. He is particularly interested in the application of machine learning and artificial intelligence in digital pathology to improve the accuracy of developing and interpreting high complexity and high-density biomarkers for clinical trials and companion diagnostics.
  In addition to what the CRO of the future will look like, we discuss the role of digital pathology in clinical trials, multi-omics and the development of companion diagnostics. Will digital pathology play a supportive role, or will it be the centerpiece?
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=DW3T3ERP-NT57B9

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• SEASON 3, EPISODE 6 - Rudy Hovelinck - Going Over the Regulatory Cliff: Accommodating Multiple File Formats

  Oct 5th 2023

  What is the state of the industry in 2023 in terms of driving towards unified file formats? Is middleware or software to bridge between various components and file formats still necessary and if so for how long? Why do we even have different file formats? Is it a feature or a bug?
  
  Rudy Hovelinck is the CEO of Pathomation, where he directs the company efforts to deliver high quality universal digital pathology software for use in education and biomarker training, life science research and routine diagnostics. His lifelong ambition is to launch products that make a true difference in cancer patient care.
  
  We're going to be talking about unified file formats or the lack thereof; How middleware serves to bridge the gap between various components in the digital pathology pixel pathway; What is involved in regulatory certification of software products in digital pathology and how it benefits customers; What steps are needed in achieving various regulatory certifications such as CE IVD or FDA clearance; What are the risks involved in embarking on such an endeavor and what advice Rudy would have for startups or other young companies seeking to develop software products in a regulated environment.
  

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• SEASON 3, EPISODE 5 - Heather Couture, PhD - Knowing The Place for the First Time

  Feb 23rd 2023

  “We shall not cease from exploration and the end of all our exploring will be to arrive where we started and know the place for the first time”
  - TS Eliot.
  
  Is it possible to predict molecular biomarkers from H&E sections through deep learning and computer vision? After all the Hematoxylin and Eosin section was one of our first tools in our arsenal. Molecular diagnostics came center stage in the 1990s and 2000s. Can we know can we now go back to the H&E and predict the molecular features?
  
  Our guest is Heather Couture of Pixel Scientia, where she accelerates machine learning projects for pathology startups. She has a PhD in Computer Science and has published in top-tier computer vision and medical imaging venues. She is the host of the Impact AI Podcast and writes regularly on LinkedIn, for her newsletter Pathology ML Insights, and for a variety of other publications.
  
  We're going to be talking about artificial intelligence and computer vision in digital pathology. First of all, what do we even mean by artificial intelligence? What is the difference between AI, a computer program, or simply just crunching large amounts of data? How do we develop tools for digital pathology; what are some of the challenges and pitfalls? And yes the “V” word - what do we mean by validation? How do we go about validation in the digital era?
  
  And finally, what about those pesky preanalytical factors? Will it even be possible to develop new tools without standardizing or accounting for variability in tissue processing, staining, and scanning?
  

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• SEASON 3, EPISODE 4 - Jason Hornick, MD, PhD - The Future of Publishing and Pathology Education

  Nov 14th 2022

  Amidst this digital transformation in pathology, it’s not only the review of histologic sections that is going digital and moving online, but practically everything else is too. What does this mean for the future of publishing and pathology education with the advent of online content and delivery mechanisms?
  
  Our guest is Jason Hornick, MD, PhD, Director of Surgical Pathology and Immunohistochemistry at Brigham and Women's Hospital, Professor of Pathology at Harvard Medical School, a pathologist with expertise in soft tissue tumor pathology, gastrointestinal pathology, and diagnostic immunohistochemistry. He is the Editor-In-Chief of the 5th series of the AFIP Atlases of Tumor and Non-tumor Pathology. Dr. Hornick serves on 14 editorial boards, including the American Journal of Surgical Pathology and Modern Pathology. He is dedicated to the advancement of diagnostic surgical pathology, and teaching approaches to diagnostic pathology to trainees and practitioners
  
  We’re going to be talking about the mission and history of the American Registry of Pathology, the publishers of the beloved fascicles atlases of tumor and non-tumor path now in its fifth series.
  
  What is the future of publishing going to look like with the advent of online content which can be updated much more frequently than the traditional 5-to-10-year cycle of publishing hard copies of books? What does online content social media and other forces mean for peer review and scientific authority? And what is the future of education going to look like not only for pathology trainees but also education for all pathologists?
  

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• SEASON 3, EPISODE 3 - Nathan Buchbinder - The New CPT Codes and What They Mean for Digital Pathology

  Oct 19th 2022

  One of the biggest pieces of news we've gotten in 2022 is the announcement of new CPT codes from the American Medical Association specifically for digital pathology. What are CPT codes? Why should we care? How will these new codes help us to elevate the practice of anatomic pathology and allow us to more concretely articulate a value proposition for digital pathology?
  
  Our guest is Nathan Buchbinder, Chief Product Officer and cofounder at Proscia. We discuss the new CPT codes and much more. We get a current lay of the land for digital pathology in mid-2022. How far have we come in the past five years or so? How far have we come in the past year - which has seen dramatic changes and acceleration in many areas. How do the US and Europe differ in adoption and outlook and what are some continuing barriers to the adoption of digital pathology?
  

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• SEASON 3, EPISODE 2 - Brandon Suh, MD - The Learning Unit

  Sep 21st 2022

  Conquering cancer through Artificial Intelligence is the goal of our guest this week on Digital Pathology today. We're talking with Brandon Suh, MD, CEO of Lunit, a South Korean company creating applications utilizing Artificial Intelligence in both digital pathology as well as radiology.
  
  Lunit stands for “learning unit,” which is fundamental to the company's philosophy which embodies the belief that they can learn just about anything and is foundational to the Artificial intelligence, which involves continuous learning.
  
  The company has developed algorithms focusing on disease screening in the areas of mammography and chest X-ray in radiology and predictive and prognostic markers in digital pathology - in particular an AI based algorithm for immunotherapy, which outperforms the current standard of care.
  
  Lunit is looking to capitalize on the growing trend of Artificial Intelligence in medicine.

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• Season 3, Episode 1 - Dr. Kevin Sandeman - The Incredible Digital Transformation of the Region Skane, Sweden

  Sep 12th 2022

  As we kick off this third season of digital pathology today our guest is Dr. Kevin Sandeman, from the Region Skane in Sweden, who is going to be taking us through their digital transformation.
  
  The Region Skane covers a population of over 1.4 million people, involves four health care systems including two academic and two community centers. The caseload is over 110,000 cases per year - generating over 680,000 scanned slides. This is a wonderful story, and the benefits are maybe not what you would expect.
  
  In addition to the obvious benefits of not having to he tethered to a microscope, according to Dr. Sandeman, the number one benefit resulting from the digital transformation is “Peace of Mind.”
  The departments in the region enjoyed much higher quality in terms of histologic preparations and output, enhanced engagement and understanding among the histotechnologists, reduction of hystertechnologist FTE requirements and complete elimination of the need to work overtime. Turnaround time for case reporting has dropped an astounding 33% and clinician satisfaction is remarkably increased.
  
  We also talked about some of the challenges in adopting the digital workflow not to mention the IT infrastructure requirements and storage demands but at the top of the list appeared to be the initial pathologist resistance to adopting the digital workflow.
  

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• SEASON 2, EPISODE 31 - Beatrice Knudsen, MD, PhD - Opportunities in Digital and Computational Pathology

  May 23rd 2022

  The digital transformation in pathology is well underway but what kind of opportunities does this present to us? We've heard all the buzz words such as machine learning artificial intelligence and heard all the hype about enhanced workflows and making pathologists’ lives easier. What is the future practice of pathology going to look like?
  
  Our guest is Beatrice Knudsen, MD, PhD, Medical Director of Digital and Computational Pathology at ARUP Laboratories, as well as Professor of Pathology at the University of Utah. Dr. Knudsen has built a program that integrates histopathology, multiplex tissue staining, digital image analysis, as well as computational pathology. She is applying this approach to close the gap between laboratory research and clinical care and to develop novel algorithms for diagnosis, prognosis and the treatment of patients.
  

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• SEASON 2, EPISODE 30 - Angelique Levi, MD and Sudhir Perincheri, MBBS, PhD - The Robustness and Suitability of AI Algorithms for Clinical Practice

  May 16th 2022

  They're coming - AI and machine learning algorithms in digital pathology.
  How do we go about assessing the robustness and suitability of these new tool for use in actual clinical practice?
  
  Our guests are Dr. Angelique Levi, Associate Professor of Pathology and Vice Chair and Director of Pathology Outreach Services and Dr. Sudhir Perincheri, Assistant Professor of Pathology and Director of Digital Pathology, both from Yale School of Medicine.
  
  We're talking about how new tools are going to be incorporated into clinical practice, and the impact of these new tools in various practice settings, such as academic medical centers, community outreach, and private practice. What does this mean for the training of the next generation of pathologists? We're only human, after all, but what about machine algorithms? What level of mistakes or "misses" is allowable? And what if these tools are too sensitive, could they actually slow us down and make life more complicated for us?
  

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• SEASON 2, EPISODE 29 - John Wirthlin - The End To End Solution

  May 7th 2022

  Too many systems or components in a pathology workflow adds complexity and cost. How can we create an elegant end to end solution to enhance workflows, while decreasing both complexity and costs?
  
  Our guest is John Wirthlin, CEO of Lumea, a company reimagining pathology - beginning and ending with the patient.
  
  We discuss the end-to-end solution in digital pathology. One of the promises of digital pathology is making the pathologist’s workflow more streamlined and more efficient. But can we bring the Laboratory Information System (LIS) into the clinic and improve the workflow flow for our clinician colleagues as well. How can we improve the tissue handling or preanalytic phase of testing? It's often easy to forget who the customer is. By utilizing enhanced workflows, can we improve satisfaction for the clinician, who is ultimately treating the patient?
  

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• SEASON 2, Episode 28 - Michael Quick - What About Digital Cytology?

  May 2nd 2022

  Amidst this digital transformation in pathology the talk seems to be largely centered around whole slide imaging of H&E-stained tissue sections. But what about cytology? Why don't we hear much talk about digital cytology, and what are some of the unique challenges in cytology in terms of going digital.
  
  Our guest is Michael Quick, Vice President of Research and Development and Innovation at Hologic.
  
  We discuss the history and evolution of cervical cancer screening all the way from pap smears to thin prep to incorporating digital pathology and image analysis in the process. Will we finally be able to say goodbye to the light microscope? And what are some of the parallels and lessons learned comparing cervical cancer screening by cytology in pathology to breast cancer screening by digital mammography in radiology.
  

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• SEASON 2, Episode 27 - Louis Culot - Surprises Big and Small

  Apr 21st 2022

  What is going to surprise us in digital pathology in big ways and in small ways? How can seemingly small changes make a big impact in what we do as pathologists and in the lives of patients? How are we going to make use of the large datasets that we will inevitably be generating through the widescale adoption of digital pathology?
  
  Our guest is Louis Culot, General Manager for Genomics and Oncology Informatics at Phillips.
  
  We're going to be talking about the current landscape of digital pathology in 2022, where we've been in the past 20 years and even earlier, and the impact of the COVID-19 global health emergency on the acceleration of the adoption of digital pathology. And what is the future of integrated diagnostics, incorporating digital pathology radiology and molecular diagnostics.
  

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• Season 2, Episode 26 - Coleman Stavish - The Image Management Platform

  Apr 8th 2022

  It's easy to get caught up in the hype surrounding digital pathology. But what is actually involved and going digital?
  What are the steps involved? We know about scanners and viewing images, of course. But what other pieces of software might be necessary or helpful?
  
  Coleman Stavish is co-founder and CTO at Proscia, a leading provider of digital and computational pathology solutions.
  At Proscia, Coleman works with a team of engineers and scientists who develop enterprise software in use at leading laboratories and large biopharma companies around the world, as well as novel image classification.
  
  We're going to be talking about workflows in digital pathology and the importance of the image management platform. What are the considerations in going digital, how can all of our software work together and how can we truly realize the promise of digital pathology by incorporating AI algorithms and other tools?

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• SEASON 2, EPISODE 25 - Craig Rhodes - The Cambridge 1 Supercomputer and Accelerating the Adoption of AI in Healthcare

  Mar 31st 2022

  NVIDIA is involved in computer graphics, artificial intelligence, computing and processors across variety of industries including gaming, entertainment, finance, and health care. What are the commonalties of all these industries and what lesson from other fields can we apply to healthcare? Our guest is Craig Rhodes EMEA Industry Lead - AI for Healthcare and Life Sciences at NVIDIA.
  
  There is the perception that healthcare lags other industries in terms of AI applications. Is this true or is it a misconception? How is AI changing healthcare now and for the future How can we accelerate the adoption of AI and new technologies in health care?
  
  NVIDIA has launched Cambridge-1 - a powerful supercomputer in the UK. We will learn about this and what results we can expect from Cambridge one in the difference this will make in healthcare in the lives of patients.
  

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• SEASON 2, EPISODE 24 - Drs. David Harrison and Gareth Bryson - Digitizing the Clinical Service and Creating a Slide Sharing Network Across Scotland

  Mar 25th 2022

  Our guests are Dr. Garth Bryson Consultant Pathologist and Clinical Director for Laboratory Medicine at the NHS Greater Glasgow and Clyde and Dr. David Harrison, Professor of Pathology from the University of Saint Andrews, and both from ICAIRD - the Industrial Center for Artificial Intelligence Research and Digital Diagnostics a program matching AI solutions and research with health and social care priorities across Scotland.
  
  We talk about the long journey of implementing digital pathology in a large health care system, barriers to adoption of digital pathology, the promise of artificial intelligence, the business case for digital pathology – have we finally been able to articulate one? And finally, we discuss our guests’ experience so far in creating a digital slide sharing network throughout Scotland.
  

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• SEASON 2, EPISODE 23 - Anant Madabhushi, PhD - Breaking Down silos and Democratizing Access to Diagnostics

  Mar 17th 2022

  Our guest is one of the giants in the field of digital pathology and image analysis. And if he has seen further than others, he will tell you, it is because he was able to stand on the shoulders of giants as well. His unique multidisciplinary approach has allowed him to breakdown silos and see across the often-artificial barriers and distinctions imposed by academic disciplines and patient treatment paradigms.
  
  We're talking with Professor Anant Madabhushi, Director of the Center for Computational Imaging and Personalized Diagnostics and Professor of Biomedical Engineering, Radiology, Pathology Urology and Radiation Oncology at Case Western Reserve University.
  
  We discuss silos in academic departments and disease states and how looking beyond these limitations can propel progress. What exactly is image analysis, what if we've been able to do with it so far and what predictive and prognostic information can we unlock from histologic features. And finally, how can an image analysis and non-tissue destructive computational and AI powered methods help to democratize access to care and lead to better outcomes for patients across the world.
  

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• SEASON 2, EPISODE 22 - Richard Lash, MD - What Have We Been Waiting For?

  Mar 10th 2022

  What have we been waiting for? What's taking so long? Much of the technology surrounding digital pathology has been with us for over 20 years. After fits and starts and initial excitement we've been left with disappointment in the past ten years. But now, it seems like the tide is turning and the digital transformation is here.
  
  Our guest is Richard Lash, MD, Chief Medical Officer from Lumea, a company re-imagining pathology by developing a comprehensive end to end workflow. Dr. Lash has had a long career as a pathologist as well as holding leadership positions in addition to Lumea at several prominent organizations including Inform Diagnostics, Ameripath and Mount Sinai Medical Center.
  
  We're going to be talking about how the lack of a cohesive business for digital pathology, lack of a vision to integrate exciting new technologies into everyday workflows has hindered the adoption of digital pathology; what has changed and why now with compelling new technologies including artificial intelligence, we can finally begin to develop and incorporate end to end solutions that can enhance pathologist performance and improve outcomes for doctors and patients.
  

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• SEASON 2, EPISODE 21 - Gabe Siegel - Augmented Reality in Digtial Pathology

  Mar 4th 2022

  We've all seen it in science fiction movies and maybe somewhat in consumer tech culture with things like Google glasses, or Pokémon GO. Augmented reality – an enhanced version of the physical world through the use of digital visual elements - does it have a role in digital pathology?
  
  Gabe Siegel is the CEO and co-founder of Augmentiqs, a company that develops augmented reality and digital pathology capabilities for the existing microscope. Prior to starting Augmentiqs, Gabe worked for multiple medical device and digital pathology companies, focusing on marketing strategy and communications. Gabe developed the concept for augmented reality microscopy & microscope-based digital pathology.
  
  We discuss what exactly is augmented reality? What are the benefits - can it really save time and money?
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=14EGFHOF-LDKUIK9

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• SEASON 2, Episode 20 - Vikram Butani - Digital Imaging Begins in the Gross Room

  Feb 25th 2022

  In this digital transformation of pathology, much of the focus is, of course, on the imaging of histologic sections or glass slides, which were once viewed under the microscope. It's often easy to forget that the examination of the specimen begins much earlier in the process - in the gross room or even in the operating room.
  
  Our guest is Vikram Butani, CEO and founder of Kubtec, whose passion is developing transformative specimen imaging, and specimen radiography systems that enable medical professionals to provide the best quality of care for their patients.
  
  Kubtec has developed range of advanced specimen radiography systems provide high resolution specimen X-ray for the biopsy suite, the operating room, the pathology gross room and the morgue. In addition, KUBTEC Specimen Radiography Systems include proprietary workflow management tools to help reduce turnaround time and labor costs.
  
  We're going to be talking about the history of Kubtec from humble beginnings, what the digital transformation of radiology has meant for imaging in other parts of the hospital - specifically the pathology gross room and the OR. We discuss the critical role of the pathologist’s assistant in the diagnostic process, the value of specimen imaging and how it can impact cost, time and efficiency. And finally, what does the future hold? and how will 3D imaging enhance what we do and ultimately bring better care to patients?
  

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• SEASON 2, EPISODE 19 - Keith Wharton Jr, MD, PhD - The Crossroads Between Immune-Oncology and Digital Pathology

  Feb 17th 2022

  The big trend in oncology over the past few years has been immunotherapy. this trend is converging with the digital transformation we are undergoing in pathology we seem to be at the crossroads of immune-oncology, digital pathology, image analysis, artificial intelligence, and the increasing ability to Multiplex.
  
  Our guest is Keith Wharton Jr., MD, PhD from Ultivue, a company looking to reveal actional biology through multiplex immunofluorescence to make immunotherapy a reality for patients with cancer. Keith is a board-certified anatomic pathologist with diverse achievements in research, drug and diagnostic development, and clinical investigation. He leads Ultivue’s Pathology and Biomarker Analytics team.
  
  We’ll be discussing what is the need for multiplexing. How much information can Multiplexing add above and beyond standard methods. When do we reach the point of diminishing returns? what are some challenges to implementation and risks of complexity and system failure? In addition, we'll talk about specific applications for immunofluorescence and multiplexing versus the current state of the practice including immunohistochemistry and quantifying tumor infiltrating lymphocytes on good old-fashioned H&E sections.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=ILQNPNFX-OB6GVI

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• SEASON 2, EPISODE 18 - COL Joel Moncur, MD, PhD and Katie Olson - Digitizing the Nation's Oldest Tissue Repository

  Feb 10th 2022

  The Armed Forces Institute of Pathology (AFIP) was in existence from 1862 to 2011. Many of us in pathology know it as the publisher of the “tumor fascicles” or the Atlas of Tumor Pathology series, originating in 1947, as well as a center of consultation and tissue repository unparalleled in the world.
  
  The AFIP was reborn as the Joint Pathology Center (JPC), whose mission is to deliver cost-effective, high-quality, multidisciplinary pathology consultation and education; and preserve, modernize, and grow the nation's oldest tissue repository to promote biomedical research. The JPC is home to the largest collection of human pathologic specimens in the world, unparalleled in size, age, and diversity. The challenge now is to digitize this collection.
  
  In this episode of Digital Pathology Today, our guests are COL Joel Moncur, Director of the Joint Pathology Center and Katie Olson, Acting Director of the Defense Digital Service (DDS).
  
  Dr. Moncur became the Director of the JPC in August of 2018. His priorities as Director include digitally transforming the JPC repository and ethically using the data to develop collaborative artificial intelligence algorithms that can lead to new insights into specific disease states or clinical scenarios.
  
  At DDS, Katie Olson oversees products and operations for the 80-person rapid-response team working within the Office of the Secretary of Defense. As a Highly Qualified Expert (HQE), Olson brings both her government and private sector experiences to bear on these important initiatives.
  
  We discuss the history of the AFIP through its disestablishment in the early 2000s and its rebirth as the JPC. What is DDS and what types of projects do they work on? The massive undertaking which many people are excited about is the project to digitize the JPC collection. We’ll learn about the size, scope and goals of the project. And, of course, artificial intelligence (AI) is a very hot topic - particularly in digital pathology. How will AI be incorporated in this project?

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• SEASON 2, EPISODE 17 - Yves Sucaet, PhD - In Search of The Standard File Format

  Feb 3rd 2022

  We hear that multiple file formats or perhaps, more importantly, lack of a uniform file format seems to be a big issue in digital pathology. Why is this? What do we even mean by a file format? And will we be able to overcome this barrier on the road to full scale adoption of digital pathology?
  
  Yves Sucaet, a PhD in Bioinformatics, has a research background in systems and network biology. In 2012, he became intrigued with the idea of applying bioinformatics algorithms to virtualized microscopic material (whole slide images).
  
  Back in Belgium, he went on to co-found Pathomation, together with Dr. Wim Waelput and Dr. Mark Kockx. The mission of Pathomation is to provide software (middleware) for digital pathology, allowing any organization to efficiently implement any digital pathology workflow imaginable.
  
  We discuss why there are multiple file formats and the challenges this causes. Do different types of applications necessitate different file formats? (i.e. 2d vs. 3-d imaging, H&E staining vs. fluorescence?) How does evolving technology and new vendor specific applications create problems? And of course, DICOM seems to be the most talked about format. Why has it become the standard in radiology but not pathology?
  

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• Season 2, Episode 16 - Gideon Ho, PhD - The World’s First Fully Automated, Quantitative, Stain-Free Imaging System.

  Jan 27th 2022

  Imagine a world without staining… in the excitement of digital pathology we often forget that we're using with a legacy system of staining tissue pink and purple, which is time-consuming and tissue-destructive. There's got to be a better way.
  
  Our guest is Dr. Gideon Ho, who co-founded HistoIndex to develop and commercialize the world’s first fully automated, quantitative, stain-free imaging system.
  
  Under his direction as the CEO, the laser-based stain-free imaging system has been
  successfully implemented in academic, clinical and commercial research centers in major universities, hospitals and research facilities around the world. Dr. Ho has multiple patents and journal publications in medical imaging, lasers and optics to his credit.
  
  We’re going to discuss the promise of Stain-free digital pathology and the technologies developed at Histoindex. What is multiphoton technology? What is second harmonic generation (SHG)? The clinical applications Histoindex is focusing on first is NASH – nonalcoholic steatohepatitis. What is NASH? what is the unmet need? How does it affect society. What are the diagnostic challenges?
  

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• SEASON 2, EPISODE 15 - Michael Feldman, MD, PhD - The digital Fellow

  Jan 20th 2022

  What is The State of the Practice of digital pathology as we enter 2022? Where are we in terms of integrated workflows, predictive and prognostic algorithms based on H&E morphology, and incorporating AI into workflows or diagnostic assistance?
  
  Perhaps most pressingly, have we finally made the business case for wide scale adoption of digital pathology?
  
  Our guest is Michael Feldman, MD, PhD, Professor of Pathology and Laboratory Medicine at the University of Pennsylvania as well as Vice Chair for Clinical Services and Director of the office of Pathology Informatics. We're going to be talking about all these things and in addition perhaps a perspective on digital pathology in an academic setting. Will digital fellows become a reality - artificial intelligence enabled machines that will organize, prepare, preview, maybe even diagnose cases and prepare the report for sign out? We’ll discuss what image analysis and computational algorithms mean for the diagnostic acumen of trainees in the next generation of pathologists.
  

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• SEASON 2, EPISODE 14 - Hannah Gilmore, MD - Digital Pathology in a Large Hospital System Covering a Vast Geography

  Jan 13th 2022

  In addition to interpreting patient biopsies and signing out cases, pathologists perform a wide variety of functions - including intraoperative consultation or frozen section, presenting cases at tumor boards or other conferences, doing procedures, or assessing the adequacy from image guided biopsies. This is done in a wide variety of practice settings. Many times, it's done over a very large geographical area where the physical presence of a pathologist may be impractical or highly inconvenient.
  
  Our guest is Hannah Gilmore, MD, Chief of the Division of Anatomic Pathology at University Hospitals Case Medical Center in Cleveland. We’re talking about the unique challenges and pain points pathologists face in the large hospital system covering a large geography. How can digital pathology help alleviate some of these challenges? What are specific applications that, if implemented, would give us immediate benefit? How can digital pathology make pathologists more productive - particularly in areas not strictly related to primary diagnostic activity?
  

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• Season 2, Episode 13 - Hamid Tizhoosh, PhD - AI and Supervised vs. Unsupervised Learning

  Jan 6th 2022

  We welcome back Professor Hamid Tizhoosh from KIMIA Lab and now of the Mayo Clinic. Dr. Tizhoosh was one of our most popular guests from last season. We talked about artificial intelligence, but it seems like we barely scratched the surface.
  
  AI is such a hot topic - so before we go any further, we’ll go back to a rough definition of Artificial Intelligence. In Machine learning a theme we keep hearing about is supervised vs. unsupervised learning. What does that mean and why is it important? The concept of validation is critically important in pathology and laboratory medicine. What does this mean in the context of Artificial intelligence? What is image archiving? And how does image search work? We discuss the difference between tissue representation and patient representation and why this distinction will be critical for the future of digital pathology and moving precision medicine forward.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=7CA0TXVI-Q1CQ5MI

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• SEASON 2, EPISODE 12 - Brian Jackson, MD - The Ethics of Artificial Intelligence

  Dec 2nd 2021

  We all want to do the right thing - but how do we know what that is? What is ethics and what is the difference between ethics and the law?
  
  Our guest is Brian Jackson, MD, medical director of IT, business development and support services at ARUP, as well as associate professor of Pathology and adjunct associate professor of biomedical informatics at the University of Utah.
  
  We're talking about the foundational principles of ethics in science and medicine. What are the limits of informed consent as it applies to developing new products utilizing patient data? Is technology evolving faster than our ability to regulate it? How do we get comfortable with and regulate algorithms and devices that appear opaque or black box?
  
  And what will the future hold as we increasingly have the ability and responsibility to develop these great new tools to help patients?
  

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• SEASON 2, EPISODE 11 - Rish Pai, MD, PhD - Engaging Pathologists in AI Algorithm Development

  Nov 25th 2021

  We keep hearing that one of the promises of digital pathology is the ability to develop AI based algorithms and tools that will allow us to do things that we never have before. This gets many people excited in the industry - particularly computer scientists, programmers and machine learning specialists - but what about the role of the pathologist? How can we the keep pathologist engaged in the development of AI algorithms and digital pathology workflows?
  
  One of the things that has hindered surgical pathology (maybe just in perception) is lack of standardization and reproducibility both in terms of molecular and IHC testing as well as interpretation of H&E images. Part of the promise of digital pathology is that we could eliminate this variability or subjectivity. But wouldn't pathologist developing their own algorithms recreate similar problems?
  
  Rish Pai, MD, PhD is Professor of Laboratory Medicine & Pathology and serves as a Consultant Pathologist at the Mayo Clinic, Arizona and Associate Chair of Research. Dr. Pai has lectured nationally and internationally on many aspects of gastrointestinal and hepatic pathology and has directed multiple GI and Liver CME courses. He is Past-President of the Rodger C. Haggitt Gastrointestinal Pathology Society. Dr. Pai is a regular reviewer for numerous pathology and gastroenterology journals and serves on the Editorial Board of the American Journal of Surgical Pathology. He has published 130 articles and written multiple book chapters in the fields of gastrointestinal and hepatic pathology.
  
  Pathology is a unique specialty. Much of what we do becomes a “permanent record,” and yet there remains an inherent subjectivity and imperfection. Do we have a special obligation to get it right?
  

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• SEASON 2, EPISODE 10 - Michael Valante - Creating the Ecosystem and Infrastructure for Digital Pathology

  Nov 18th 2021

  Our guest is Michael Valante, Global Business Leader for Dell Technology’s Healthcare Division and Dell’s Chief Technology Officer for Digital Pathology, where he is a subject matter expert in the areas of enterprise imaging and pathology informatics. Mike is deeply focused on the healthcare industry and the intersection of medical imaging and information technology.
  
  We’re going to discuss lessons learned from Dell’s involvement in IT infrastructure throughout healthcare and disciplines outside of pathology. Digital Pathology, as a field is, moving incredibly fast. It seems like we’ve hit an inflection point in the past year. We’ll discuss the trajectory and the velocity of the digital transformation.
  
  Pathology certainly has different stakeholders – lab managers, hospital administrators, IT staff, the pathologists, other physicians. Roughly what are the concerns of each of these varied groups of stakeholders? And what is Dell’s approach to balancing both the technical and clinical aspects of digital pathology?
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=CEPBAI5N-44PLDI

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• Season 2, Episode 9 - Katir Patel, PhD - Enabling Immune-oncology

  Nov 11th 2021

  Immunotherapy and immune-oncology have become such hot areas of exploration in the past few years. We're going to explore the forces which have coalesced to make this a reality.
  
  Our guest is doctor Katir Patel, PhD a scientist with a keen interest in immunotherapy and diagnostics. We're going to be exploring the role of digital pathology in immune-oncology. How will we use the tools in our arsenal, such as image analysis, multiplexing, artificial intelligence and even good old-fashioned H&E sections to bring pathology to the forefront of immune-oncology.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=YYYLIJ1-9BVUZ0K9

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• Season 2, Episode 8 - Hillel Kahane, MD - Leveraging AI in Actual Clinical Practice

  Nov 4th 2021

  There's so much excitement and hype around AI, but what does it mean for the practicing pathologist?
  
  Workflows seem very fragmented and antiquated, particularly in this new era of digital pathology. Can we add value in the pre-analytic or specimen handling phase and also in the post-analytic or reporting phase?
  
  Our guest is Hillel Kahane, MD, founder of Starpath diagnostics, a renowned and well-respected board certified uropathologist with over 28 years of experience in the commercial USA laboratory industry. He has personally signed out over 1,000,000 prostate needle biopsies throughout the USA serving well over 6,000 urologists and radiation oncologists nationwide. Dr. Kahane has served as the Chief Medical Officer & Director of Uropathology at Acupath Laboratories, Medical Director of Bostwick Laboratories, and Executive Medical Director, Uropathology DIANON Systems- LabCorp.
  
  There seem to be many different use cases for AI. We’re going to discuss potential to enhance workflows, quality assurance application and primary diagnosis. Pathologists have long been changed to their desks and microscopes. What is the future of remote sign-out? Pathologists are very good at what they do, but how can we improve upon conventional light microscopy? And can come up more innovative ways of capturing the value we have created?
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=H5B6IO5Z-9HEHFR

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• Season 2, Episode 7 - Deploying AI-Powered Image Analysis in Drug Development

  Oct 28th 2021

  There is so much rich information imbedded in the histologic and molecular features of tissue sections which can be extracted through digital pathology. We seem to be at the convergence of AI-powered image analysis and precision medicine.
  
  Our guests are Jonathan Daniels and Ori Zelikov, MD from Nucleai, who are committed to bringing the power of spatial biology to reality by providing pharmaceutical companies and clinicians with AI- powered image analysis applications.
  
  We're going to be talking about the promise of digital pathology and image analysis and how these technologies can be leveraged in drug discovery and ultimately patient care. What does the future hold and how a higher throughput of patient biopsies through a digital pathology system will result in a new age of information and discovery analogous to the revolution we have seen in sequencing the human genome. We will also talk about the rich ecosystem in med-tech in Israel and what makes Nucleai unique in its makeup and approach.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=IFYSMY5K-R6BT9

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• Season 2, Episode 6 - Colin White, PhD and Frank Gannon, MD - Open the Floodgates

  Oct 21st 2021

  The technology in digital pathology has been with us for some time. It now, though, seems we've hit an inflection point and things are accelerating. Perhaps we are even in the perfect storm. There seems to be a certain sense of inevitability and it may be time to open the floodgates and release the promise of digital pathology.
  
  Our guests are Colin White - Senior Vice President and General Manager, Advanced Staining & Imaging at Leica Biosystems and Frank Gannon, Professor of Pathology at Baylor College of Medicine in Houston Texas.
  
  Colin White is an IVD industry veteran with more than 20 years of experience in conceiving, developing and commercializing systems that advance the practice of pathology. Colin’s passion is innovation and motivating teams to develop solutions that advance patient care whilst also meeting the needs of healthcare providers and regulating bodies.
  
  Dr. Gannon has over 25 years’ experience as a practicing pathologist with subspecialty expertise in Orthopedic Pathology. Prior to joining Baylor College of Medicine in Houston Texas, he spent 8 years at the Armed Forces Institute of pathology in Orthopedic Pathology, 2 years as chair of the department. Dr. Gannon is co-author on an Orthopedic Pathology book, numerous book chapters, and over 110 publications in peer reviewed journals.
  
  We’re going to be talking about the value proposition of digital pathology.
  
  What are the challenges to implementation? What’s been holding us back and are these barriers beginning to crumble? What does digital pathology mean for patient involvement?
  
  And we're going to be talking about artificial intelligence, machine learning, remote sign out, remote case sharing and what going digital means in terms of workflows for the typical pathology department.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=6E6PY8ZM-CBIT3XR

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• Season 2, Episode 5 - Esther Abels - Regulatory Update and Path Visions 2021

  Oct 14th 2021

  Our guest is Esther Abels, Chief Clinical Officer and Chief Regulatory Officer at Visiopharm, as well as the president-elect of the Digital Pathology Association.
  
  Esther also leads the regulatory and standards task force at the DPA with a focus on FDA collaborations to drive regulatory and standard classifications for interoperability and computational pathology in the field of digital pathology.
  
  We're going to be talking about standardization in digital pathology - not only in preanalytical factors such as fixation and staining - but also in the interpretive or analytic component, as well which is becoming increasingly important to ensure optimal diagnostic results for patients and incorporation of digital pathology data into diagnostic and drug discovery programs.
  
  We discuss regulation. What are some misconceptions about regulation how can we use regulation as a tool to protect patients and better develop and provide products and services? And how can we partner with regulators to help advance the science.
  
  What is the DPA working on now and what is their long-term vision for the future of the field? The annual meeting of the Digital Pathology Association, Pathology Visions is going to be held this October in Las Vegas.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=DITLKQI9-UQMPLDI

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• SEASON 2, EPISODE 4 - Elizabeth Neyens, DVM, DABT - Preparing Your Disaster Plan in Digital Pathology

  Oct 7th 2021

  Is your lab or institution ready for a disaster?
  
  Dr. Elizabeth Neyens has over 15 years of experience in translational drug development and has held various staff pathology positions in contract research organizations, the pharmaceutical industry and as well as research institutes worldwide.
  
  Dr. Neyens currently supports academia, biotechnology and pharmaceutical companies with a variety of nonclinical services at Flanders ToxPath Consulting. She is an active scientist on social media and keeps a blog and has been a regular on podcasts about Pathology & Toxicology.
  
  We are talking about preparing your disaster plan in digital pathology. What is data Integrity and why is it important? How do we keep our data safe? What types of threats do we face in the areas of drug development and digital pathology?
  
  We talk about cloud computing - the bad, the good and the ugly. And how can we prepare for the unexpected such as climate disasters and pandemics where stakeholders are suddenly shifted from an office environment to working from home?
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=27WGROOH-MTV5CDI

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• SEASON 2, EPISODE 3 - David Tulman, PhD - Beyond Paraffin

  Sep 30th 2021

  With digital pathology, we are utilizing new methods to view images acquired from a very old technology - Hematoxylin and Eosin stained sections from formalin fixed paraffin embedded tissue, which have been prepared the same way for over 100 years.
  
  This method actually adds steps, time and expense. But what if we could also reinvent the way we handle tissue to instantaneously view images from samples without having to process to fix and process them in the traditional way?
  
  Can we move beyond paraffin?
  
  David Tulman is a biomedical engineer, cancer researcher, and entrepreneur. He earned a PhD in Bioinnovation from Tulane University, focusing on the development of novel microscopy systems for point-of-care pathology evaluations.
  
  David is a founder of Instapath, a company that formed in 2017 to build and commercialize systems that image pathology tissue without fixing or cutting. Instapath operates out of the Texas Medical Center in Houston.
  
  Instapath introduces an innovative solution utilizing optical scanning microscopy to evaluate the composition of the entire fresh sample within minutes at the point-of-procedure and preserve it for downstream testing.
  
  David is also the host of beyond the scope of the podcast from the digital pathology association will talk to him about that as well as the upcoming DPA annual meeting, Pathology Visions, this October in Las Vegas.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=AVM8B2C0-5REJYVI

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• SEASON 2, EPISODE 2 - JOHN WALLER, PHD - ENHANCING DECISION MAKING IN R&D WITH DIGITAL PATHOLOGY

  Sep 24th 2021

  Our Guest is John Waller, PhD, Chief Operations Officer & Founder of Oracle Bio.
  
  John has over of 15 years as a biology project leader in the pharmaceutical industry, for companies including AstraZeneca and Merck & Co. He has expertise in the integration of translational biomarkers into drug discovery programs and considerable experience in developing in vitro, ex vivo and in vivo models involving image analysis across numerous therapeutic areas.
  
  OracleBio is a global leader in quantitative digital pathology, providing image analysis services to Pharma and Biotech clients worldwide. Leveraging multiple software platforms, the company delivers robust data packages within a quality management framework to support clinical trials and translational research. As image analysis experts, OracleBio specializes in cellular phenotyping of multiplex stained tissue and has built a strong reputation as the go-to company for complex image analysis.
  
  Their mission is to enhance decision making within R&D by leveraging Digital Pathology to deliver robust data and actionable insights.
  
  We are talking about the role of digital pathology in drug development and drug discovery. What are machine learning and deep learning? How are they different from artificial intelligence? And what role do they play in image analysis and digital pathology? How is Multiplexing evolving, what are its limits and how is it going to change what we do? What is the need for cloud computing in digital pathology? What are the advantages and disadvantages of putting our data and processes into the cloud?
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=398W1TVB-F5PZAOR

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• Season 2, Episode 1 - Jonhan Ho, MD - Democratizing Pathology

  Sep 17th 2021

  One of the missing links in this digital transformation has been robust platforms for pathologists to interact with one another to share images and cases.
  
  KIKO, which stands for “knowledge in, knowledge out” is a slide hosting and sharing platform with many uses, including education, case and other content sharing, the ability to consult with colleagues, and even storing your own cases for later retrieval.
  
  Sites like KIKO help to democratize pathology and knowledge, which has been one of the key themes of this digital transformation. It also serves to enhance the careers of individual pathologists.
  
  Dr. Jonhan Ho is the Director of the Dermatopathology Division and the Fellowship Director at the University of Pittsburgh Medical Center. Throughout his career, he has trained hundreds of pathology and dermatology residents, and dermatopathology fellows. Having experienced the joy of teaching but also the frustrations of institutional silos, he founded KiKo, to democratize medical training and teaching in an easy-to-use platform. His hope is that through KiKo, doctors can begin to take back medical knowledge instantly and privately in order to make each other better.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=GP0UV7FE-QFFLXR

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• Episode 35 - Leo Grady, PhD - Making Digital Pathology AI Native

  May 27th 2021

  We're talking with Leo Grady, CEO of Paige, a company developing AI-based solutions in digital pathology to optimize patient outcomes. We're going to be talking about his experiences in diagnostics, radiology, pathology, and artificial intelligence. We’ll discuss the early history of Paige, its relationship with memorial Sloan Kettering, what products Paige is developing, what the future holds, and their strategy for developing partnerships.
  
  It’s often said that radiology is at least a decade ahead of pathology in terms of going digital. But is this accurate or fair? Radiology images, after all are digitally native whereas pathology images are not. What do we mean by digitally native? What do we mean by AI native? is it possible to create an AI native environment for digital pathology?
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=HP720Z3R-J0PB9

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• Episode 34 - Special Edition - New Guidelines for Validating Whole Slide Imaging - Andrew Evans. MD, PhD and Nicole Thomas, MPH - College of American Pathologists

  May 20th 2021

  The College of American Pathologists (CAP), in collaboration with the ASCP and API announced the 2021 update of guidelines for Validating Whole Slide Imaging (WSI) for diagnostic Purposes.
  
  We talk with Andrew Evans, MD, PhD, Chair of The Digital and Computational Pathology Committee and Nicole Thomas, MPH, Director of the CAP Center for Evidence Based Guidelines.
  
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=1UAFDPAE-49GGB9

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• Episode 33 - Dennis Strenk - The People of Pathology

  May 13th 2021

  Dennis Strenk is the host of the People of Pathology Podcast and Pathologists’ Assistant at the Wisconsin Diagnostic Laboratories.
  
  Dennis has created a unique podcast to get to know the people in pathology , to understand their motivations, and to hear their stories and learn from their insights.
  
  We talk with him about the origins of the People of Pathology Podcast, lessons learned and the surprises along the way.
  
  In addition, we talk about digital pathology, gross specimen handling and imaging and how new technologies such as digital pathology can enhance workflows.
  
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=CVJYPTWU-KCHAOR

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• Episode 32 - Michael Johnson, PhD - Digital Pathology and the Use of 3D Imaging, Multiplexing and Organoids

  May 6th 2021

  This episode we speak with Dr. Michael Johnson of Visikol. We will discuss 3D imaging in digital pathology. We will look at the current and future uses of 3D imaging. What is the current state of the art in multiplexing - particularly for clinical use. We will find out more about organoids, what they are and what role they play in research and finally, what Visikol has in store for the future.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=4LASXV8V-Y4IY66R

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• Episode 31 - Jerad Gardner, MD - The Evolving Role of Social Media in Digital Pathology

  Apr 29th 2021

  One of the many features of digital pathology is the capacity for increased connectivity among and between pathologists and the ability to share and collaborate on images and cases. This lends itself very nicely to the use of social media. We will examine the way pathologists use YouTube, Twitter, Facebook and other platforms including pathology specific ones such as PathPresenter and KIKO.
  
  We will look at how, in the past 10 years, social media has evolved and helped shape the practice, discuss how social media will continue to enhance the field of pathology as well as the careers of individual pathologists.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=KLEIOUVA-T0GGB9

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• Episode 30 - Special Edition - Gestalt Diagnostics and MindPeak partner to deploy AI in cancer diagnostics

  Apr 27th 2021

  We're speaking with Felix Faber of MindPeak and Lisa-Jean Clifford of Gestalt Diagnostics.
  
  With the recently announced partnership between Gestalt, MindPeak, and Leica for the implementation of digital pathology for Bio-Reference Laboratories, we will talk about this real world use of artificial intelligence and algorithms. We discuss how this collaboration will increase workflow efficiency and accuracy for pathologists. We will examine their AI integration for remote breast cancer diagnostics and the algorithms they will be utilizing.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=45SM4BV9-KB4VX6R

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• Episode 29 - Chaim Linhart, PhD - The AI Revolution

  Apr 22nd 2021

  Our guest is Chaim Linhart of IBEX Medical Analytics. We will discuss the unique challenges and opportunities for unlocking the tools of digital pathology. We examine the differences between a strong AI and narrow AI and how strong AI can assist pathologists.
  
  Why is AI the "killer app" in digital pathology and how did Ibex develop Galen, one of the first AI based solutions to be deployed in actual clinical practice.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=3O0N6OIP-OGMYGB9

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• Episode 28 - Anil Parwani, MD, PhD, MBA - Connecting the Dots

  Apr 15th 2021

  With so many use cases and applications in digital pathology, how do we connect the dots and make it all work?
  
  Dr. Anil Parwani is Professor of Pathology at The Ohio State University, Vice chair of Pathology and Head of Anatomic Pathology. He is the newly elected president of the Digital Pathology Association (DPA).
  
  We will talk about some of the ways to increase adoption and possible use cases for digital pathology. We will examine how algorithms and AI tools might help and what will be the role of pathologists if these algorithms work as promised. We will also look at some of the barriers to adoption including interoperability and storage.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=8QZYF2TV-Y7AM7VI

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• Episode 27 - Patrick Myles - Image Search and Digitizing the Joint Pathology Center Archives

  Apr 8th 2021

  We are talking with Patrick Myles, the CEO of Huron Digital Pathology. In this episode, we will discuss searching images within digital pathology. We will talk about slide indexing in handling large image databases and how these new searches will open the door to democratizing digital pathology. We will examine image search for new drug discovery, clinical use, and research applications.
  
  We will also look at the new project to digitize the Joint Pathology Center's archive of glass slides.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=JEA50PZW-M5CDI

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• Episode 26 - Thomas Barr, Industry Innovation

  Apr 1st 2021

  Tom Barr is an industry veteran. He was an early adopter of digital pathology - utilizing various hardware platforms as well as commercial and custom software.
  
  We will look at some of the early challenges to whole slide imaging (WSI), software solutions, networking, storage and interoperability
  
  Tom was instrumental in developing VIPER (Virtual Imaging for Pathology Education and Research) at Nationwide Children's Hospital and developing the digital pathology network used in clinical trials for many of the large cooperative groups as well as The Cancer Genome Atlas (TCGA)program.
  
  He is currently a founder at HyperPath Solutions.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=GHNNDI19-1C3DI

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• Episode 25 - Special Edition - Proscia CEO, David West and Ibex Medical Analytics CEO, Joseph Mossel, Discuss Partnership

  Mar 26th 2021

  We are talking with David West, CEO of Proscia and Joseph Mossel, CEO of IBEX Medical Analytics.
  
  Recently, Proscia, a leading provider of digital and computational pathology solutions, and IBEX Medical Analytics, a pioneer in artificial intelligence (AI)-based cancer diagnostics, announced a strategic partnership to support pathologists in detecting prostate cancer.
  
  In this episode, we will learn about the history of these two companies, examine how this partnership will work to help pathologists and patients and where this will lead digital pathology in the future.
  
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=5V338L4U-EB6S9K9

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• Episode 24 - Hamid Tizhoosh, PhD - What is AI?

  Mar 18th 2021

  Our guest is Professor Hamid Tizhoosh, the director of the KIMIA Lab (Laboratory for Knowledge Inference in Medical Image Analysis) at the University of Waterloo.
  
  We've all heard the hype about Artificial Intelligence (AI), but what exactly is AI?
  
  In this episode, we will examine some examples of AI in everyday life. We will discuss the current and future applications of artificial intelligence in digital pathology and image analysis, the "ethics" of artificial intelligence, and why the pathologist will not be replaced anytime soon.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=3F7ABE9P-L6W7Y14

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• Episode 23 - Ahmed Hosny - Why AI? Why now? Evaluating the Landscape of AI Startups in Digital Pathology

  Mar 11th 2021

  Our guest is Ahmed Hosny, a machine learning research scientist, author and blogger from the Dana Farber Cancer Institute, who has a developed a framework for evaluating AI startups.
  
  This episode, we are talking about artificial intelligence (AI), machine learning (ML), and deep learning. We will touch on the history of AI and how it has been used to train neural networks.
  
  Pathology seems to be behind radiology with the number AI start-ups. We will find out some of the reasons why. We will discuss how the lack of format standards in imaging has slowed the growth of AI and we will examine potential uses of AI in clinical, academic and research environments.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=IMS5FW7L-WH4CXR

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• Episode 22 - Steven H. Hinrichs, MD - Building a Team

  Mar 3rd 2021

  Our guest is Dr. Steven Hinrichs, Professor and Chair in the Department of Pathology and Microbiology at the University of Nebraska.
  
  This episode, we focus on creating an effective team to transition to digital pathology. We will learn what types of teams are needed and the challenges in building those groups.
  
  We also look at the psychology of pathology. We will examine how the brain processes black & white images and how that impacts the new era of machine learning.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=A2AC6NZP-DNDN29

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• Episode 21 - Sam Terese - Early Adopters

  Feb 25th 2021

  Our guest is Sam Terese, president and CEO of Alverno Laboratories, an integrated laboratory delivery network serving multiple healthcare systems and hospitals in the Chicagoland and Indiana area. Sam Terese has more than 30 years of experience in the laboratory environment, including settings as varied as community hospitals, academic medical centers, as well as research based organizations. Alverno, under Sam's leadership, has pursued a strategy of growth and consolidation and offers laboratory medicine, anatomic pathology services, as well as molecular diagnostics.
  
  This episode, we're going to be talking about considerations in going digital. We will examine the advantages of digital pathology to a healthcare system, and the opportunities for improving efficiencies and consolidation. Alverno was an early adopter in taking its anatomic pathology services digital, so we will discuss what it means to be an early adopter. We will look at how digital pathology can enhance the care that pathologists provide to doctors, patients and healthcare systems. We'll discover some considerations in establishing a relationship in a digital pathology platform provider because clearly as we're going to learn, it's not a one-off transaction or a one-time thing, but an ongoing relationship or even a foundation upon which we can build.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=BZNZCS7R-8478PVI

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• Episode 20 - Mariano de Socarraz - Putting AI into Clinical Practice

  Feb 18th 2021

  Our guest is Mariano de Socarraz, president of CorePlus Servicos Clinicos y Patologicos. With over 25 years experience in anatomic pathology, CorePlus is an international specialty laboratory serving clients in the US and the Caribbean.
  
  This episode, we are talking about the digital journey that CorePlus underwent. We will discover what were the steps involved, once the decision was made to go digital, what lessons were learned and of course, what is the business case for going digital.
  
  The big news of course, is CorePlus made the first installation of an AI system for clinical use in the Americas. We will examine what the system is going to do, what are the use cases in practical applications and what are the gains and benefits we can expect.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=6760G4RK-UH257B9

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• Episode 19 - Cory Roberts, MD - Making the Leap

  Feb 11th 2021

  Our guest is Dr. Cory Roberts, CEO, Chairman and President of ProPath. He is a pathologist with over 20 years of experience in healthcare ranging from academic medicine to specialty private practice and currently leading ProPath, the largest 100% physician owned pathology and laboratory medicine diagnostic practice in the country.
  
  This episode, we are talking about what it takes to go digital in a large group practice. In 2020, ProPath made the leap into digital pathology. We will discover what lessons were learned, what was the business case for digital pathology, what will move the needle ultimately in putting digital pathology into practice, and we will talk about industry forces and consolidation in the laboratory business and what the future is going to look like.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=JH5RKUU3-N4GQFR

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• Episode 18 - Marilyn Bui, MD, PhD - A Holistic Approach to Digital Pathology

  Feb 4th 2021

  Our guest is Dr. Marilyn Bui from Moffitt Cancer Center a pathologist with expertise in sarcoma, pathology, cytopathology, breast cancer biomarker testing as well as digital pathology.
  
  In this episode, we are going to talk about the holistic approach to digital pathology. We will find out if digital pathology is more than the sum of its parts.
  
  We will discuss the benefits derived from being highly connected with our systems, our networks or devices, our colleagues and even ultimately, the customers that we serve.
  
  In addition, we will look at ways to encourage our colleagues, physicians and other specialties to get on board with digital pathology. We also examine ways to engage the customers we serve to get them active and excited about the digital transformation that's underway.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=5DT62HN5-RHBMX6R

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• Episode 17 - Enabling Immuno-Oncology- Roberto Salgado, MD, PhD - International Immuno-Oncology Biomarker Working Group

  Jan 28th 2021

  Roberto Salgado, MD, PhD is a pathologist based in Belgium with expertise in breast pathology and immuno-oncology. He is Co-chair of the International Immuno-Oncology Biomarker Working Group.
  
  Over the past several years we have seen large advances and dedication of resources to immuno-oncology. We’ve also seen that information extracted by quantifying Tumor Infiltrating Lymphocytes (TILs) on routine histologic sections adds significant predictive and prognostic information in this area.
  
  We have known for over a hundred years, however that assessment of histologic features adds powerful information correlated with patient outcomes. Are we poised for a renaissance in histologic examination, with digital pathology as the engine?

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=HHAM3BKH-NJYVI

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• Episode 16 - Breaking News- Will FDA Relax Regulations on slide Scanning Systems? - Richard Morroney of Inspirata

  Jan 26th 2021

  The global COVID-19 public health emergency brought about many changes including a relaxation of FDA regulation of slide scanners and displays in digital pathology.
  
  A notice was recently placed in the Federal Register by the FDA through Health and Human services soliciting a 90-day comment period to discuss permanently waving FDA regulation over certain medical devices.
  
  We will be discussing the significance of these possible changes with Richard Morroney, Director of Regulatory Compliance at Inspirata.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=AX1VZB4Q-M9M5CDI

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• Episode 15 - Rajendra Singh, MD - Connectivity and PathPresenter

  Jan 21st 2021

  Dr. Singh is a Professor in Dermatology and Pathology at Northwell Health, New York. He directs the Dermatopathology Section and is the Associate Chair of Digital Pathology. He is board certified in pathology and dermatopathology and board eligible for Clinical Informatics. He is the Founder of PathPresenter, an online digital platform that has 125,000+ users in 170+ countries and is used by multiple academic departments, private pathology groups and organizations in the US and all over the world.
  
  We’re going to learn about PathPresenter. What was the unmet need that facilitated its creation. One of the features of digital pathology particularly connectivity among and between pathologists is democratizing access to care , which can mean making the benefits of surgical pathology review available to underserved populations and also making expertise in diagnostics available to fellow pathologists.
  
  Many pathologists present cases to tumor board or other multidisciplinary conferences. What challenges and opportunities does this create? And how will pathology education change with increased connectivity and on-demand access to digitally archived images?

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=JL3E12GZ-9MGQFR

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• Episode 14- Markus Herrmann, MD, PhD - Unlocking Computational Pathology

  Jan 14th 2021

  We're talking with Dr. Markus Herrmann, Assistant Professor of Pathology at Harvard Medical School, and director of computational pathology at Mass General Hospital.
  
  At the heart of digital pathology is the transformation of images into data. And in so doing, we've unlocked the exciting field of computational pathology.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=572B39TG-7TX1OR

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• Episode 13 - Jacob Abel, MD - Meet Your New Microscope?

  Jan 7th 2021

  As we move toward full scale adoption of digital pathology, it has been said that the computer monitor is going to replace the microscope. If true, that could make the display or monitor one of the most important pieces of equipment.
  
  This episode of Digital Pathology Today™ we will focus on monitors and displays, the different levels and grades (consumer vs. medical), how displays are evaluated, the pixel pathway, and the FDA role.
  
  We are talking with Jacob Abel of University of Michigan whose primary interest is the selection, assessment, and calibration of displays (monitors) in digital pathology.
  
  Find out more on Digital Pathology Today™

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=EZ4TJO0C-TYY14I

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• Episode 12 - Special 2020 Year-end Recap

  Dec 31st 2020

  This special year end addition will feature a look back add some of the hot topics and memorable guests we've had on the podcast.
  
  We'll go way back - over 100 years - to the foundations of pathology and look at what pathology as a discipline has done very well and what the future will hold.
  
  We'll look at comparisons of pathology to radiology in terms of barriers to adoption and timelines in converting to digital systems.
  
  2020 was a memorable year, and the most striking event or series of events were related to the global COVID-19 pandemic which facilitated remote sign-out for primary diagnosis. Were we ready for this global health emergency? Regulatory barriers, specifically CLIA and FDA regulations were temporarily waived to facilitate the immediate adoption telepathology.
  
  We’ll look at regulation and the emerging field of Regulatory Sciences and hopefully clear up some of the misconceptions. If someone is going to regulate the space it might as well be us. How can we use regulation as a tool to fuel innovation and not as a detriment or hindrance? And we will uncover the truth of the much talked about global shortage of pathologists.
  
  This special episode will feature previous guests Tony Magliocco, Ajit Singh, Matthew Hanna, Joe Lennerz, Mark Tuthill, Michael Isaacs and Dan Milner.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=10MFPYZR-B28IWWM

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• Episode 11 - Dr. Mark Lloyd- Working Together for a Better Workflow

  Dec 24th 2020

  One of the buzz words associated with digital pathology is, of course, "workflows." In this episode of Digital Pathology Today, we will examine the components and considerations of workflows that a pathology group has to consider before implementing a digital pathology system. We will discuss interoperability and how pathology groups and hospital systems can maximize their investment and future- proof the investment to protect against downside along the way.
  
  We are talking with Dr. Mark Lloyd, the founder of Inspirata, who had a vision of developing and delivering innovative solutions to transform the cancer experience for doctors and patients.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=FIZXKXJH-6YLDI

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• Episode 10 - Elizabeth Neyens, DVM, DABT - Digital Pathology in Drug Development

  Dec 17th 2020

  Our guest this episode is Dr. Elizabeth Neyens, a toxicological pathologist who focuses on pre-clinical research, histopathological evaluation, due diligence, digital pathology as well as quality assurance expertise.
  
  This episode we will look at toxicological pathology and the role of digital pathology in drug development. We will discuss the job of a toxicological pathologist and how it has shifted during COVD-19. We will also look at the use of artificial intelligence in drug development.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=4K22USG6-TIYSYVI

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• Episode 9, Michael Isaacs - Hurdles for Integration

  Dec 10th 2020

  This episode will be examining fully integrated digital pathology systems with Michael Isaacs. We discover what this system will look like and what it will mean compared to the analog model. We will discuss the business case and return on investment for full scale adoption for varying usage and size.
  
  Michael Isaacs is the Director of Clinical Informatics and Business Development from the Department of Pathology at Washington University School of Medicine in St. Louis. He has a computer background and over 25 years experience supporting information technology in the laboratory. His primary interest is providing strategic vision for the implementation of digital pathology to health care systems and to better meet patients needs. He has been on the board of directors of the Digital Pathology Association for the past five years and is currently the co-chair for the education committee for the DPA.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=FY6WRCEP-AS8AOR

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• Episode 8, Dan Milner, MD, CMO of the ASCP – The Global Practice of Digital Pathology

  Dec 3rd 2020

  Our guest this week is Dan Milner, MD, MSc, Chief Medical Officer of the ASCP.
  Dr. Milner has been heavily involved in pathology capacity building in many countries and, most notably, led the team that built anatomic pathology laboratories in Rwanda and Haiti for advanced cancer diagnostics.
  
  Before joining ASCP, Dr. Milner spent 10 years at Harvard where he was the primary lead for infectious disease consultations in AP and CP; and was the recipient of numerous research grants and the author of over 100 publications.
  
  We’re talking about the global practice of pathology - challenges and opportunities in implementing laboratory systems in both the developed and developing world.
  
  We seem to be at a unique position to take advantage of improvements in technology and digital pathology to add enormous value to the lives of the doctors and patients we serve as pathologists.
  
  We’ll talk about what the future holds for the profession of pathology. What is the truth about reports of the much talked about impending shortage of pathologists? Will technology make much of what we do obsolete? Who will be the beneficiaries of new applications in artificial intelligence? Will pathologists become the conductors of the orchestra of medicine?

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=H6IMLYQ0-SJ1YVI

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• Episode 7 - Mark Tuthill, MD - What is Informatics?

  Nov 25th 2020

  Our guest this week is Dr. Mark Tuthill, head of Pathology informatics at Henry Ford Health System. Dr. Tuthill is member of the CAP-Education committee, the ASCP Informatics Council and the API leadership council.
  
  He has extensive experience in: anatomic and clinical pathology laboratory information systems, digital imaging systems for pathology practice, computer networking, mobile computing networks, and computer-based education.
  
  We’re going to be talking about informatics – what exactly is informatics and what does it mean in the context of digital pathology? How will digital pathology systems be integrated with laboratory information systems and how does this differ from the analog model?
  
  What will workflows look like in digital pathology? What are the complexities? What are the dangers? and what are we most likely not thinking about? And of course, what are the barriers we face in making this all work?

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=3OVHOBF8-3WPZAOR

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• Episode 6 - Joe Lennerz, MD, PhD - Rethinking Regulation

  Nov 19th 2020

  Our guest this week is Dr. Joe Lennerz, Associate Chief of Pathology and the Medical Director of the Center
  for Integrated Diagnostics (CID) at Massachusetts General Hospital (MGH). He oversees all aspects of the clinical laboratory service that supports personalized medicine at MGH.
  
  He was the principal investigator of the first FDA instrument precision study for the first whole slide
  scanning system.
  
  We're talking about Regulatory matters in digital pathology, the various regulatory bodies at play and the alphabet soup of regulation such as CLIA, CAP , FDA, GDRP and so forth. What is the 21 st century cures act and how does it impact digital pathology? And many folks may be
  surprised to learn about new initiatives such as the Digital Health Center of Excellence at the FDA, designed to spur innovation.
  
  We’ll learn about the Alliance for Digital Pathology - A regulatory science initiative to harmonize and standardize digital pathology processes to speed up innovation to patients.
  
  In the past it's been tempting for many of us to think of regulation as a burden but is this mode of thinking outdated? By proactively forming partnerships with regulatory bodies will we actually be able
  to spur innovation and advance the state of the Science?

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=2N8YCPZ3-8AQ69A4

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• Episode 5 - Matthew Hanna, MD - Moving to Remote Digital Signout

  Nov 11th 2020

  Our guest this episode is Dr. Matthew Hanna, Director of Digital Pathology Informatics and breast pathologist at Memorial Sloan Kettering Cancer Center.
  
  Dr. Hanna serves as a member on the CAP Informatics Committee as well as an editor for the Journal of Pathology Informatics. We will be discussing his experience in the digital pathology program at Memorial Sloan Kettering as well as recent advances in digital sign out.
  
  What is the current status digital sign out - from a practical as well as regulatory standpoint? What obstacles and resistance have we faced in remote sign out? And of course, what are the implications of the global COVID-19 pandemic?
  
  Were pathologists ready for remote sign out? What regulatory barriers came down to facilitate adoption. And which - if any - of these gains will become standard practice once the pandemic is over?
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=9MW5IQT7-13JTT9

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• Episode 4 - Pathology Visions 2020 Meeting Recap

  Nov 5th 2020

  In this special edition of Digital Pathology Today, we're recapping Pathology Visions 2020 - the premier meeting in digital pathology, which is, of course, put on by the Digital Pathology Association (DPA).
  
  We'll be talking with Abbey Norris, the executive director of the Digital Pathology Association and Michael Rivers of Roche Tissue Diagnostics and the current president of the DPA. Abbey and Michael were instrumental in organizing this year's virtual meeting.
  
  If there's one theme that's emerging, it’s that digital pathology is a reality in 2020. It is no longer pie-in-the-sky talk about what might happen at some point in the future. It is a reality in the practice of medicine in 2020. Changes in terms of adoption and innovation are only being accelerated by vast improvements in technology and artificial intelligence applications.
  
  The global pandemic has certainly accelerated adoption - specifically remote sign out of actual patient cases in clinical practice.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=CSHIJ8KZ-ZR529

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• Episode 3 - Ajit Singh, PhD - Artificial Intelligence Applications in Digital Pathology - The Future is Now

  Oct 28th 2020

  Ajit Singh has had a vast variety of experiences in digital pathology as well as digital radiology - in both operations and venture capital. He was President and CEO at BioImagene, a digital pathology company acquired by Roche, and CEO of digital radiology and medical informatics at Siemens healthcare.
  
  He is a partner at Artiman Ventures, focusing on early stage Technology and life sciences investments. Dr. Singh also serves as adjunct professor at the Stanford University School of Medicine, and is on the Board of Trustees of the AACR
  
  He joins us to talk about similarities and differences between the two visually based diagnostic specialties, pathology and radiology, challenges and opportunities as it applies to the global workforce shortage of pathologists in both the developed and developing world , as well as practical applications of artificial intelligence in digital pathology, and why the future might be here sooner than you may think.
  

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=CBA9QYNH-YLOW29

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• Episode 2 - Anthony Magliocco, MD - The Evolving Role of Digital Pathology in Personalized Medicine

  Oct 22nd 2020

  Dr. Anthony Magliocco has had a career spanning over 30 years and is an internationally recognized expert in developing and deploying advanced diagnostics to help cancer patients.
  
  Prior to founding Protean Bio diagnostics, Dr. Magliocco was chair of Pathology and Executive Director of Esoteric Laboratory Services at Moffitt Cancer Center. In addition, he served as Scientific Director of Moffitt Cancer Center Tissue Core and founded new fellowships in molecular diagnostics as well as digital image analysis.
  
  Dr. Magliocco has published over 200 manuscripts, which have been cited over times 10,000 times in the scientific literature.
  
  We're going to be talking about the evolving role of the pathologist in the setting of personalized medicine.
  What has pathology, as a field, done well, in terms of providing tools and solutions to assist clinicians and patients in individualizing treatment options?
  
  What opportunities are there for change or improvement amidst, the massive growth and opportunity in the field of personalized medicine. Will our expanding capabilities in image analysis and the promise of artificial intelligence enable us to create new and powerful tools to diagnose disease and guide therapy?
  
  Have we finally turned the corner in incorporating diagnostics two large prospective randomized trials which will allow us to develop and validate powerful tools to refine our prognostic and predictive capabilities? Does image analysis and the ability to Multiplex open up a whole new world of possibilities to create more powerful tools than we ever imagined? And what does the future hold?

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=IJNZZS7B-SF9A4I

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• Episode 1 - Liron Pantanowitz, MBBCh - Digital Pathology - Where Have We Been Over the Past 20 Years?

  Oct 15th 2020

  In this special first episode we will be talking with Dr. Liron Pantanowitz, from the University of Michigan about where digital pathology has been over the course of the past 20 years, seminal developments and advances in whole slide image and image analysis.
  
  We will discuss why it is taking so long for the full scale adoption of digital pathology in the clinical setting. In addition, we will examine the parallels and differences between the specialties of pathology and radiology, the benefits of switching to a fully digitized system, and what are the practical considerations of going digital.
  
  We will also touch on regulatory concerns, the current state of AI applications, recent acceleration during the COVID-19 pandemic and how Dr. Pantanowitz sees the field evolving over the next 10 years and beyond.

  episode link (current time)   ☞   https://cast.rocks/hosting/28647/feeds/JY3PA.html?ep=8W9H0DWD-29H33DI

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